Marwan Ghabril, Justin Nguyen, David Kramer, Trina Genco, Martin Mai, Barry G. Rosser – 28 November 2007 – The liver's role as the largest organ of metabolism and the unique and often critical function of liver‐specific enzyme pathways imply a greater risk to the recipient of acquiring a donor metabolic disease with liver transplants versus other solid organ transplants. With clinical consequences rarely reported, the frequency of solid organ transplant transfer of metabolic disease is not known.

Ian Homer Y. Cua, Jacob George – 28 November 2007

Anna Wieckowska, Arthur J. McCullough, Ariel E. Feldstein – 28 November 2007

José A. Solís‐Herruzo, Inmaculada García‐Ruiz – 28 November 2007

Mirjam B. Zeisel, George Koutsoudakis, Eva K. Schnober, Anita Haberstroh, Hubert E. Blum, François‐Loïc Cosset, Takaji Wakita, Daniel Jaeck, Michel Doffoel, Cathy Royer, Eric Soulier, Evelyne Schvoerer, Catherine Schuster, Françoise Stoll‐Keller, Ralf Bartenschlager, Thomas Pietschmann, Heidi Barth, Thomas F. Baumert – 28 November 2007 – Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Scavenger receptor class B type I (SR‐BI) has been shown to bind HCV envelope glycoprotein E2, participate in entry of HCV pseudotype particles, and modulate HCV infection.

Tina L. Sumpter, Masanori Abe, Daisuke Tokita, Angus W. Thomson – 28 November 2007 – Interstitial liver dendritic cells (DCs) exhibit phenotypic diversity and functional plasticity. They play important roles in both innate and adaptive immunity. Their comparatively low inherent T cell stimulatory ability and the outcome of their interactions with CD4+ and CD8+ T cells, as well as with natural killer (NK) T cells and NK cells within the liver, may contribute to regulation of hepatic inflammatory responses and liver allograft outcome.

Carlo Selmi, M. Eric Gershwin, Keith D. Lindor, Howard J. Worman, Ellen B. Gold, Mitchell Watnik, Jessica Utts, Pietro Invernizzi, Marshall M. Kaplan, John M. Vierling, Christopher L. Bowlus, Marina G. Silveira, Ilaria Bossi, USA PBC Epidemiology Group – 28 November 2007 – Primary biliary cirrhosis (PBC) is generally a slowly progressive disease that may lead to cirrhosis and liver failure.

Nadia Gorman, Adrian Zaharia, Heidi S. Trask, Juliana G. Szakacs, Nicholas J. Jacobs, Judith M. Jacobs, Dominic Balestra, Jacqueline F. Sinclair, Peter R. Sinclair – 28 November 2007 – Porphyria cutanea tarda is a liver disease characterized by elevated hepatic iron and excessive production of uroporphyrin (URO). Phlebotomy is an effective treatment that probably acts by reducing hepatic iron. Here we used Hfe(−/−) mice to compare the effects on hepatic URO accumulation of two different methods of hepatic iron depletion: iron chelation using deferiprone (L1) versus iron‐deficient diets.

Jason Chamberlain, Takashi Yamagami, Evan Colletti, Neil D. Theise, Jyoti Desai, Ana Frias, John Pixley, Esmail D. Zanjani, Christopher D. Porada, Graça Almeida‐Porada – 28 November 2007 – Alternative methods to whole liver transplantation require a suitable cell that can be expanded to obtain sufficient numbers required for successful transplantation while maintaining the ability to differentiate into hepatocytes. Mesenchymal stem cells (MSCs) possess several advantageous characteristics for cell‐based therapy and have been shown to be able to differentiate into hepatocytes.

Samir Zakhari, Ting‐Kai Li – 28 November 2007 – More than 70% of alcohol is consumed by 10% of the population in the United States. Implicit in this statistic is that tremendous variation in the pattern of drinking (quantity, frequency, and duration) exists among alcohol consumers. Individuals who are binge or chronic drinkers will have different health outcomes than social drinkers. Therefore, knowing the pattern of drinking will shed light on how severely individuals are alcohol‐dependent and on the extent of liver damage.