Peroxisome proliferator‐activated receptor‐β/δ protects against chemically induced liver toxicity in mice

Weiwei Shan, Christopher J. Nicol, Shinji Ito, Moses T. Bility, Mary J. Kennett, Jerrold M. Ward, Frank J. Gonzalez, Jeffrey M. Peters – 26 December 2007 – Potential functional roles for the peroxisome proliferator‐activated receptor‐β/δ (PPARβ/δ) in skeletal muscle fatty acid catabolism and epithelial carcinogenesis have recently been described. Whereas PPARβ/δ is expressed in liver, its function in this tissue is less clear.

Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome

Florence Wong, Kevin Moore, Jasper Dingemanse, Rajiv Jalan – 26 December 2007 – Renal vasoconstriction is a key factor in the development of hepatorenal syndrome (HRS) and may be secondary to increased activities of endothelin‐1, a potent renal vasoconstrictor.

Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion

Yuan Zhai, Bo Qiao, Feng Gao, Xiuda Shen, Andrew Vardanian, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 26 December 2007 – We have documented the key role of toll‐like receptor 4 (TLR4) activation and its signaling pathway mediated by interferon (IFN) regulatory factor 3, in the induction of inflammation leading to the hepatocellular damage during liver ischemia/reperfusion injury (IRI). Because type I IFN is the major downstream activation product of that pathway, we studied its role in comparison with IFN‐γ.

Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver

Gianluca Perseghin, Guido Lattuada, Francesco De Cobelli, Antonio Esposito, Elena Belloni, Georgia Ntali, Francesca Ragogna, Tamara Canu, Paola Scifo, Alessandro Del Maschio, Livio Luzi – 26 December 2007 – Fatty liver is characterized by metabolic abnormalities at the liver, but also at skeletal muscle and adipose tissue sites.

Minocycline and N‐methyl‐4‐isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition

Tom P. Theruvath, Zhi Zhong, Peter Pediaditakis, Venkat K. Ramshesh, Robert T. Currin, Andrey Tikunov, Ekhson Holmuhamedov, John J. Lemasters – 26 December 2007 – Graft failure after liver transplantation may involve mitochondrial dysfunction. We examined whether prevention of mitochondrial injury would improve graft function. Orthotopic rat liver transplantation was performed after 18 hours' cold storage in University of Wisconsin solution and treatment with vehicle, minocycline, tetracycline, or N‐methyl‐4‐isoleucine cyclosporin (NIM811) of explants and recipients.

Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia–warm reperfusion injury

Virginie Defamie, Marina Laurens, Damiano Patrono, Laurent Devel, Antoine Brault, Marie‐Christine Saint‐Paul, Athanasios Yiotakis, Pascal Barbry, Jean Gugenheim, Dominique Crenesse, Vincent Dive, Pierre‐Michel Huet, Bernard Mari – 26 December 2007 – Matrix metalloproteinases (MMPs) have been implicated in the hepatic injury induced after cold ischemia–warm reperfusion (CI‐WR), by altering the extracellular matrix (ECM), but their precise role remains unknown.

Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice?

Tito Livraghi, Franca Meloni, Michele Di Stasi, Emanuela Rolle, Luigi Solbiati, Carmine Tinelli, Sandro Rossi – 26 December 2007 – If liver transplantation is not feasible, partial resection is considered the treatment of choice for hepatocellular carcinoma (HCC) in patients with cirrhosis. However, in some centers the first‐line treatment for small, single, operable HCC is now radiofrequency ablation (RFA). In the current study, 218 patients with single HCC ≤ 2.0 cm (very early or T1 stage) underwent RFA.

Peroxisome proliferator‐activated receptor‐γ protects against hepatic ischemia/reperfusion injury in mice

Satoshi Kuboki, Thomas Shin, Nadine Huber, Thorsten Eismann, Elizabeth Galloway, Rebecca Schuster, John Blanchard, Basilia Zingarelli, Alex B. Lentsch – 26 December 2007 – The function of peroxisome proliferator‐activated receptor‐γ (PPARγ) in hepatic inflammation and injury is unclear. In this study, we sought to determine the role of PPARγ in hepatic ischemia/reperfusion injury in mice. Male mice were subjected to 90 minutes of partial hepatic ischemia followed by up to 8 hours of reperfusion. PPARγ was found to be constitutively activated in hepatocytes but not in nonparenchymal cells.

Subscribe to