Takashi Ito, Yasutsugu Takada, Mikiko Ueda, Hironori Haga, Yoji Maetani, Fumitaka Oike, Kohei Ogawa, Seisuke Sakamoto, Yasuhiro Ogura, Hiroto Egawa, Koichi Tanaka, Shinji Uemoto – 28 November 2007 – In the present study, the results of living donor liver transplantation (LDLT) for 125 hepatocellular carcinoma (HCC) patients were analyzed to determine optimal criteria exceeding the Milan criteria (MC) but still with predictably good outcomes. On the basis of pretransplant imaging studies, 70 patients met the MC, and 55 patients did not.

Francesca Bravi, Cristina Bosetti, Carlo La Vecchia – 28 November 2007

Timothy J. Davern – 28 November 2007

Veysel Tahan, Nese Imeryuz, Erol Avsar, Cigdem Celikel, Nurdan Tozun – 28 November 2007

Tomomi Yamazaki, Akiko Nakamori, Eriko Sasaki, Satoshi Wada, Osamu Ezaki – 28 November 2007 – Diets high in sucrose/fructose or fat can result in hepatic steatosis (fatty liver). We analyzed the effects of dietary fish oil on fatty liver induced by sucrose, safflower oil, and butter in ddY mice. In experiment I, mice were fed a high‐starch diet [70 energy% (en%) starch] plus 20% (wt/wt) sucrose in the drinking water or fed a high‐safflower oil diet (60 en%) for 11 weeks. As a control, mice were fed a high‐starch diet with drinking water. Fish oil (10 en%) was either supplemented or not.

Ziqiu Wang, Lisheng Ge, Meifang Wang, Brian I. Carr – 28 November 2007 – Compound 5 (Cpd 5), a K vitamin analog, has been shown to inhibit Hep3B human hepatoma cell growth in cultures and rat hepatoma growth in vivo through prolonged epidermal growth factor receptor (EGFR)–extracellular response kinase (ERK) phosphorylation, and hepatocyte growth factor (HGF) synergizes with Cpd 5 to enhance the inhibition of Hep3B cell and rat hepatoma growth.

Rongzhen Xu, Xuzhao Zhang, Wei Zhang, Yongmin Fang, Shu Zheng, Xiao‐Fang Yu – 28 November 2007 – Human APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3) cytidine deaminases have been shown to be potent inhibitors of diverse retroviruses including Vif‐deficient human immunodeficiency virus 1 (HIV‐1), hepatitis virus B (HBV), adeno‐associated virus, and endogenous retroelements.

Sumita Verma, Michael Torbenson, Paul J. Thuluvath – 28 November 2007 – The impact of ethnicity on the natural history of autoimmune hepatitis (AIH) has not been well characterized. The aim of this study was to assess the natural history of AIH in blacks in comparison with others (nonblacks). This was a 10‐year (June 1996 to June 2006) retrospective analysis of patients with AIH from a single tertiary care center. The diagnosis of AIH was defined by the criteria established by the International Autoimmune Hepatitis Club.

Sònia Tugues, Guillermo Fernandez‐Varo, Javier Muñoz‐Luque, Josefa Ros, Vicente Arroyo, Juan Rodés, Scott L. Friedman, Peter Carmeliet, Wladimiro Jiménez, Manuel Morales‐Ruiz – 28 November 2007 – Liver cirrhosis is a very complex disease in which several pathological processes such as inflammation, fibrosis, and pathological angiogenesis are closely integrated. We hypothesized that treatment with pharmacological agents with multiple mechanisms of action will produce superior results to those achieved by only targeting individual mechanisms.

Charles E. Rogler, Hong Chou Zhou, Lauretta LeVoci, Leslie E. Rogler – 28 November 2007 – Recent studies have shown a pluripotential nature of stem cells that were previously thought to be committed to specific lineages. HBC‐3 cells are a clonal fetal murine hepatoblast cell line derived from an e9.5 murine embryo, and these cells can be induced to form hepatocytes and bile ducts in vitro and when transplanted into adult mouse livers.