Vanessa Stadlbauer, Nathan A. Davies, Gavin A.K. Wright, Rajeshwar P. Mookerjee, Rajiv Jalan – 29 October 2007

Goran B.G. Klintmalm, W. Kenneth Washburn, Steven M. Rudich, Thomas G. Heffron, Lewis W. Teperman, Carlos Fasola, Devin E. Eckhoff, George J. Netto, Eliezer Katz – 29 October 2007 – This work is a 1‐yr interim analysis of a prospective, randomized, multicenter trial evaluating the effect of corticosteroid‐free immunosuppression on hepatitis C virus–positive (HCV+) liver transplant recipients following liver transplantation (LT).

Donna Beer Stolz, Mark A. Ross, Atsushi Ikeda, Koji Tomiyama, Takashi Kaizu, David A. Geller, Noriko Murase – 29 October 2007 – We evaluated the kinetics by which rat liver sinusoidal endothelial cells (LSECs) are repopulated in the reperfused transplanted liver after 18 hours of cold ischemic storage. We found that the majority of LSECs in livers cold‐stored for 18 hours in University of Wisconsin solution are seriously compromised and often are retracted before transplantation.

Azuma Watanabe, Ardeshir Hashmi, Dawidson Assis Gomes, Terrence Town, Abdallah Badou, Richard Anthony Flavell, Wajahat Zafar Mehal – 29 October 2007 – Apoptosis of hepatocytes results in the development of liver fibrosis, but the molecular signals mediating this are poorly understood. Degradation and modification of nuclear DNA is a central feature of apoptosis, and DNA from apoptotic mammalian cells is known to activate immune cells via Toll‐like receptor 9 (TLR9). We tested if DNA from apoptotic hepatocytes can induce hepatic stellate cell (HSC) differentiation.

Shih‐Ping Liu, Ying‐Shiuan Li, Yann‐Jang Chen, En‐Pei Chiang, Anna Fen‐Yau Li, Ying‐Hue Lee, Ting‐Fen Tsai, Michael Hsiao, Shiu‐Feng Hwang, Yi‐Ming Arthur Chen – 29 October 2007 – Glycine N‐methyltransferase (GNMT) affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens. To establish a Gnmt knockout mouse model, 2 lambda phage clones containing a mouse Gnmt genome were isolated.

Richard Saitz – 29 October 2007 – Addiction (e.g., alcohol or drugs) is a chronic disease. Specific behavioral and pharmacological treatments have proven efficacy.

Fred T. Lee – 29 October 2007

Avnish K. Seth, Bridget K. Gunson, Darius F. Mirza, Geoffrey Haydon – 29 October 2007 – The prevalence, natural history, and implications of reactive thrombocytosis after liver transplantation (LT) are unknown. Prospectively collected data from July 2000 to February 2006 were analyzed. Post–LT thrombocytosis was defined as a platelet count of >450 × 103/μL lasting for >7 days and starting within 8 weeks of transplantation.

Teh‐Ia Huo, Han‐Chieh Lin, Shou‐Dong Lee – 29 October 2007

Patricia A. DeRusso, Wen Ye, Ross Shepherd, Barbara A. Haber, Benjamin L. Shneider, Peter F. Whitington, Kathleen B. Schwarz, Jorge A. Bezerra, Philip Rosenthal, Saul Karpen, Robert H. Squires, John C. Magee, Patricia R. Robuck, Ronald J. Sokol, Biliary Atresia Research Consortium – 29 October 2007 – Malnutrition is a significant clinical problem in infants with biliary atresia. The natural history of poor growth and its potential association with early transplantation or death in children with biliary atresia was determined.