Liver transplantation for hepatocellular carcinoma: Role of biopsy

François Durand, Jacques Belghiti, Valérie Paradis – 29 October 2007 – Patients with compensated cirrhosis (and low Model for End‐Stage Liver Disease score) should not undergo transplantation unless they have small hepatocellular carcinoma (HCC). Therefore, presence of HCC should be definitely ascertained before deciding on transplantation in this group of patients.

ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice

Frédéric Kesteloot, Alexis Desmoulière, Isabelle Leclercq, Marc Thiry, Jorge E. Arrese, Darwin J. Prockop, Charles M. Lapière, Betty V. Nusgens, Alain Colige – 29 October 2007 – ADAMTS2 belongs to the “ADAM metallopeptidase with thrombospondin type 1 motif” (ADAMTS) family. Its primary function is to process collagen type I, II, III, and V precursors into mature molecules by excising the aminopropeptide. This process allows the correct assembly of collagen molecules into fibrils and fibers, which confers to connective tissues their architectural structure and mechanical resistance.

Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice

Ryotaro Sakamori, Tetsuo Takehara, Chihiro Ohnishi, Tomohide Tatsumi, Kazuyoshi Ohkawa, Kiyoshi Takeda, Shizuo Akira, Norio Hayashi – 29 October 2007 – Sepsis is an infection‐induced syndrome with systemic inflammatory response leading to multiorgan failure and occasionally death. During this process, signal transducer and activator of transcription 3 (STAT3) is activated in the liver, but the significance of this molecule has not been established.

Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

Jonathan M. Maher, Matthew Z. Dieter, Lauren M. Aleksunes, Angela L. Slitt, Grace Guo, Yuji Tanaka, George L. Scheffer, Jefferson Y. Chan, Jose E. Manautou, Ying Chen, Timothy P. Dalton, Masayuki Yamamoto, Curtis D. Klaassen – 29 October 2007 – Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood.

Incidence and natural course of fatty liver in the general population: The Dionysos study

Giorgio Bedogni, Lucia Miglioli, Flora Masutti, Anna Castiglione, Lory Saveria Crocè, Claudio Tiribelli, Stefano Bellentani – 29 October 2007 – Using the general population of the Dionysos Study, we followed up 144 subjects without fatty liver (FL−) and 336 with fatty liver (FL+) for a median time of 8.5 years. All subjects had suspected liver disease (SLD) defined as altered liver enzymes, high mean corpuscular volume, or low platelet count in the absence of HBV and HCV infection. Ethanol intake was assessed using a food frequency questionnaire, and FL was diagnosed using ultrasonography.

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