Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

Jonathan M. Maher, Matthew Z. Dieter, Lauren M. Aleksunes, Angela L. Slitt, Grace Guo, Yuji Tanaka, George L. Scheffer, Jefferson Y. Chan, Jose E. Manautou, Ying Chen, Timothy P. Dalton, Masayuki Yamamoto, Curtis D. Klaassen – 29 October 2007 – Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood.

Incidence and natural course of fatty liver in the general population: The Dionysos study

Giorgio Bedogni, Lucia Miglioli, Flora Masutti, Anna Castiglione, Lory Saveria Crocè, Claudio Tiribelli, Stefano Bellentani – 29 October 2007 – Using the general population of the Dionysos Study, we followed up 144 subjects without fatty liver (FL−) and 336 with fatty liver (FL+) for a median time of 8.5 years. All subjects had suspected liver disease (SLD) defined as altered liver enzymes, high mean corpuscular volume, or low platelet count in the absence of HBV and HCV infection. Ethanol intake was assessed using a food frequency questionnaire, and FL was diagnosed using ultrasonography.

Decreased white matter lesion volume and improved cognitive function after liver transplantation

Alex Rovira, Beatriz Mínguez, F. Xavier Aymerich, Carlos Jacas, Elena Huerga, Juan Córdoba, Juli Alonso – 29 October 2007 – Focal T2‐weighted white matter lesions (WML) on brain magnetic resonance imaging (MRI), mimicking those seen in cerebrovascular small‐vessel disease described in patients with persistent hepatic encephalopathy, decreased in volume with the improvement of hepatic encephalopathy. This outcome has been interpreted as a decrease in the edema that it is proposed to be involved in the pathogenesis of hepatic encephalopathy.

Outcomes of donor evaluation in adult‐to‐adult living donor liver transplantation

James F. Trotter, Karen A. Wisniewski, Norah A. Terrault, James E. Everhart, Milan Kinkhabwala, Robert M. Weinrieb, Jeffrey H. Fair, Robert A. Fisher, Alan J. Koffron, Sammy Saab, Robert M. Merion, A2ALL Study Group – 29 October 2007 – The purpose of donor evaluation for adult‐to‐adult living donor liver transplantation (LDLT) is to discover medical conditions that could increase the donor postoperative risk of complications and to determine whether the donor can yield a suitable graft for the recipient.

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