Absence of toll‐like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

Xiu‐Da Shen, Bibo Ke, Yuan Zhai, Feng Gao, Sei‐Ichiro Tsuchihashi, Charles R. Lassman, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 27 September 2007 – This study analyzes how toll‐like receptor 4 (TLR4) signaling in the donor organ affects the ischemia and reperfusion injury (IRI) sequel following liver transplantation. Isogenic orthotopic liver transplantations (OLTs) with rearterialization were performed in groups of wild‐type (WT) and TLR4 knockout (KO) mice after donor liver preservation in University of Wisconsin solution at 4°C for 24 hours.

Lessons learned from anatomic variants of the hepatic artery in 1,081 transplanted livers

Rafael López‐Andújar, Angel Moya, Eva Montalvá, Marina Berenguer, Manuel De Juan, Fernando San Juan, Eugenia Pareja, Juan José Vila, Francisco Orbis, Martín Prieto, José Mir – 27 September 2007 – The aim of this study is to contribute our experience to the knowledge of the anatomic variations of the hepatic arterial supply. The surgical anatomy of the extrahepatic arterial vascularization was investigated prospectively in 1,081 donor cadaveric livers, transplanted at La Fe University Hospital from January 1991 to August 2004.

Incidence of severe ventricular arrhythmias during pulmonary artery catheterization in liver allograft recipients

Mi Sook Gwak, Jie Ae Kim, Gaab Soo Kim, Soo Joo Choi, Hyun Ahn, Jeong Jin Lee, Sang Lee, Myung Kim – 27 September 2007 – Liver allograft recipients may develop a hyperdynamic circulation and cardiac electrophysiologic abnormalities. The incidence of severe ventricular arrhythmias in liver allograft recipients during pulmonary artery (PA) catheterization was determined. One hundred five liver allograft recipients were studied prospectively; 5 of the patients with preexisting valvular heart disease, ischemic heart disease, or arrhythmias were excluded.

Clinical characteristics of thrombotic microangiopathy following ABO incompatible living donor liver transplantation

Ryohei Miyata, Motohide Shimazu, Minoru Tanabe, Shigeyuki Kawachi, Ken Hoshino, Go Wakabayashi, Yoko Kawai, Masaki Kitajima – 27 September 2007 – Thrombotic microangiopathy (TMA) may develop after living donor liver transplantation (LDLT), but the mechanism is not fully understood. We retrospectively analyzed all patients undergoing LDLT at our center, including TMA patients, to elucidate the clinical characteristics and presentation and to determine which patients have a higher risk of occurrence of TMA. In all, 57 adult patients were reviewed after LDLT at our institution.

Can peripheral venous pressure be an alternative to central venous pressure during right hepatectomy in living donors?

Soo Joo Choi, Mi Sook Gwak, Justin Sang Ko, Gaab Soo Kim, Tae Hyeong Kim, Hyun Ahn, Jie Ae Kim, Mikyung Yang, Sang Lee, Myung Kim – 27 September 2007 – The safety of living donors is a matter of cardinal importance in addition to obtaining optimal liver grafts to be transplanted. Central venous pressure (CVP) is known to have significant correlation with the amount of bleeding during parenchymal transection and many centers have adopted CVP monitoring for right hepatectomy. However, central line cannulation can induce some serious complications.

Impact of weight‐based ribavirin with peginterferon alfa‐2b in african americans with hepatitis C virus genotype 1

Ira M. Jacobson, Robert S. Brown, Jonathan McCone, Martin Black, Clive Albert, Michael S. Dragutsky, Firdous A. Siddiqui, Thomas Hargrave, Paul Y. Kwo, Louis Lambiase, Greg W. Galler, Victor Araya, Bradley Freilich, Joann Harvey, Louis H. Griffel, Clifford A.

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