Requirement of the cyclic adenosine monophosphate response element‐binding protein for hepatitis B virus replication
Bo Kyung Kim, Seoung Ok Lim, Yun Gyu Park – 11 April 2008 – The cyclic adenosine monophosphate–response element (CRE)‐transcription factor complex participates in the regulation of viral gene expression and pathologic processes caused by various viruses. The hepatitis B virus (HBV) enhancer I directs liver‐specific transcription of viral genes and contains a CRE sequence (HBV‐CRE); however, whether the HBV‐CRE and CRE‐binding protein (CREB) are required for the HBV life cycle remains to be determined.
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Tito Livraghi – 7 April 2008
Sustained complete response and low complication rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis
Yun Ku Cho, Jae Kyun Kim – 7 April 2008
Chronic genotype 4 hepatitis C
Daniel F. Schafer – 7 April 2008
Autophagy in the liver
Xiao‐Ming Yin, Wen‐Xing Ding, Wentao Gao – 7 April 2008 – A great part of our current understanding of mammalian macroautophagy is derived from studies of the liver. The term “autophagy” was introduced by Christian de Duve in part based on ultrastructural changes in rat liver following glucagon injection. Subsequent morphological, biochemical, and kinetics studies of autophagy in the liver defined the basic process of autophagosome formation, maturation, and degradation and the regulation of autophagy by hormones, phosphoinositide 3‐kinases, and mammalian target of rapamycin.
Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?
Michael Charlton – 5 April 2008
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Karen Madsen – 2 April 2008
Multidrug resistance–associated proteins are crucial for the viability of activated rat hepatic stellate cells
Rebekka A. Hannivoort, Sandra Dunning, Sara Vander Borght, Ben Schroyen, Jannes Woudenberg, Fiona Oakley, Manon Buist‐Homan, Fiona A. J. van den Heuvel, Mariska Geuken, Albert Geerts, Tania Roskams, Klaas Nico Faber, Han Moshage – 28 March 2008 – Hepatic stellate cells (HSCs) survive and proliferate in the chronically injured liver. ATP‐binding cassette (ABC) transporters play a crucial role in cell viability by transporting toxic metabolites or xenobiotics out of the cell.
Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo
Boris Görg, Natalia Qvartskhava, Verena Keitel, Hans J. Bidmon, Oliver Selbach, Freimut Schliess, Dieter Häussinger – 28 March 2008 – Oxidative stress plays a major role in cerebral ammonia toxicity and the pathogenesis of hepatic encephalopathy (HE). As shown in this study, ammonia induces a rapid RNA oxidation in cultured rat astrocytes, vital mouse brain slices, and rat brain in vivo.