Albert Lau, Curt Bay, Abdul Nadir – 24 November 2004

Anthony T. Dann, Anna P. Kenyon, Paul T. Seed, Lucilla Poston, Andrew H. Shennan, Rachel M. Tribe – 24 November 2004 – Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease associated with poor maternal and fetal outcome. The diagnosis is based on pruritus with abnormal liver function in the absence of other pathological conditions. However, pruritus in pregnancy is common, and it may be the only presenting feature in ICP.

Gabriela De Larrañaga, Silvia Perés, Jorge Benetucci – 24 November 2004

Ruoqing Huang, Thomas D. Schiano, May Jennifer Amolat, Charles M. Miller, Swan N. Thung, Romil Saxena – 19 November 2004 – Imaging studies show complete restoration of liver volume in adult recipients of right lobe allografts within 2–3 weeks of living donor transplantation (LDLT). However, it is not known if this growth is associated with restoration of hepatic microarchitecture. We compared 21 biopsies without significant pathology from LDLT recipients with 23 biopsies from adult recipients of cadaveric donor liver transplantation (CDLT) performed within 3 months of transplantation.

Guy W. Neff, Christopher B. O'Brien, Jose Nery, Norah J. Shire, Seigo Nishida, Julia delaGarza, Marzia Montalbano, Kamran Safdar, Phillip Ruiz, Eric Rideman, Jose A. Gascon, Andreas G. Tzakis, Juan Madariaga, Steven M. Rudich – 19 November 2004 – Hepatitis C virus (HCV) is becoming the most common indication for liver retransplantation (ReLTx). This study was a retrospective review of the medical records of liver transplant patients at our institution to determine factors that would identify the best candidates for ReLTx resulting from allograft failure because of HCV recurrence.

Paige M. Porrett, Shashank S. Desai, Kathleen J. Timmins, Carol R. Twomey, Seema S. Sonnad, Kim M. Olthoff – 19 November 2004 – Through May 2004, 33 combined orthotopic heart‐liver transplants (OHT/OLT) have been performed nationwide. No published data exist to date regarding outcomes of patients awaiting such transplants, although progression of two organ disease processes may contribute to premature death for waiting patients.

Michiel P.C. Siroen, Michiel C. Warlé, Tom Teerlink, Robert J. Nijveldt, Ernst J. Kuipers, Herold J. Metselaar, Hugo W. Tilanus, Dirk J. Kuik, Joost R.M. van der Sijp, Sybren Meijer, Ben van der Hoven, Paul A.M. van Leeuwen – 19 November 2004 – Asymmetric dimethylarginine (ADMA) has been recognized as an endogenous inhibitor of the arginine–nitric oxide (NO) pathway. Its concentration is tightly regulated by urinary excretion and degradation by the enzyme dimethylarginine dimethylaminohydrolase (DDAH), which is highly expressed in the liver.

Mitsugi Shimoda, Rafik M. Ghobrial, Ian C. Carmody, Dean M. Anselmo, Douglas G. Farmer, Hasan Yersiz, Pauline Chen, Sherfield Dawson, Francisco Durazo, Steve Han, Leonard I. Goldstein, Sammy Saab, Jonathan Hiatt, Ronald W. Busuttil – 19 November 2004 – The efficacy of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) is not well defined. This study examines the variables that may determine the outcome of OLT for HCC in HCV patients. From 1990 to 1999, 463 OLTs were performed for HCV cirrhosis.

Norbert Hubert Gruener, Maria‐Christina Jung, Axel Ulsenheimer, Joern Tilman Gerlach, Reinhart Zachoval, Helmut Michael Diepolder, Gustavo Baretton, Rolf Schauer, Gerd Rudolf Pape, Carl Albrecht Schirren – 19 November 2004 – Virus‐specific CD8+ T cells play a major role in antiviral immune defenses; their significance in the transplant setting, however, is unclear.

James R. Burton, Hugo R. Rosen – 19 November 2004