Scott T. Magness, Ramón Bataller, Liu Yang, David A. Brenner – 22 September 2004 – Activation of hepatic stellate cells (HSCs) and other resident mesenchymal cells into myofibroblasts expressing alpha smooth muscle actin (αSMA) and collagen I is a key event in liver fibrogenesis. However, the temporal expression profiles of αSMA and collagen I genes in these cells is unknown.
Kim M. Olthoff, Robert S. Brown, Francis L. Delmonico, Richard B. Freeman, Sue V. McDiarmid, Robert M. Merion, J. Michael Millis, John P. Roberts, Abraham Shaked, Russell H. Wiesner, Michael R. Lucey – 21 September 2004 – A national conference was held to review and assess data gathered since implementation of MELD and PELD and determine future directions. The objectives of the conference were to review the current system of liver allocation with a critical analysis of its strengths and weaknesses.
Bruno Roche, Didier Samuel – 21 September 2004 – Key Points 1Long‐term prophylaxis with hepatitis B immune globulin (HBIG) significantly reduces the risk for hepatitis B virus (HBV) recurrence and increases survival. Patients with HBV cirrhosis and / or positive HBV DNA at the time of transplantation have a high risk for recurrence despite HBIG prophylaxis.2Pre–orthotopic liver transplantation (OLT) antiviral treatment using lamivudine (LAM) can suppress HBV replication before transplantation and may induce clinical improvement in a subset of patients.
Richard B. Freeman – 21 September 2004
Margarita Sala, Maria Varela, Jordi Bruix – 21 September 2004 – Key Points 1Liver transplantation is the main option for patients with early HCC who are not optimal candidates for surgical resection.2Shortage of donors is its main limitation, as waiting for a liver allows the tumor to progress and induce exclusion from the waiting list and death.3The absence of randomized controlled trials hinders the establishment of the most effective therapy to prevent tumor progression while waiting.4Live donation may be a cost‐effective approach if optimal results are expected and the mortality risk fo
Joseph K. Lim, Emmet B. Keeffe – 21 September 2004 – Key Points 1The 1‐year and 5‐year actuarial survival rates following liver transplantation for patients with alcoholic liver disease are 82% and 68%, respectively, in the United States and 85% and 70%, respectively, in Europe.
Simon Horslen – 21 September 2004 – Key Points 1Patients listed for combined liver and intestine transplantation have the highest waitlist mortality of any transplant candidates.2Liver‐intestine candidates have higher mortality rates than other patients listed for liver transplantation at all model for end‐stage liver disease (MELD) and pediatric end‐stage liver disease (PELD) scores, sepsis rather than liver failure being the major cause of death in this group.3Increasing PELD scores appear to correlate with increasing waitlist mortality in patients awaiting combined liver and intestinal t