Carla S. Coffin, Tram N.Q. Pham, Patricia M. Mulrooney, Norma D. Churchill, Tomasz I. Michalak – 20 September 2004 – Antibodies against virus nucleocapsid (anticore) normally accompany hepadnaviral hepatitis but they may also occur in the absence of symptoms and other serological indicators of the infection. This situation can be encountered following a clinically and serologically unapparent exposure to hepatitis B virus (HBV) or after recovery from hepatitis B.

Ke Qi, Hongming Qiu, Dongfeng Sun, Gerald Y. Minuk, Michael Lizardo, John Rutherford, F. William Orr – 20 September 2004 – Metastases rarely occur in human livers with cirrhosis in clinical studies. We postulated that this phenomenon would also occur in experimental cirrhosis. Cirrhosis was established in C57BL/6 mice by carbon tetrachloride (CCl4) gastrogavage. B16F1 melanoma cells were injected into the mesenteric vein to induce hepatic metastases. Contrary to our postulate, there was greater than 4‐fold increase in metastasis in animals with cirrhosis compared to controls.

Shiro Yokohama, Masashi Yoneda, Masakazu Haneda, Satoshi Okamoto, Mituyoshi Okada, Kazunobu Aso, Takenao Hasegawa, Yoshihiko Tokusashi, Naoyuki Miyokawa, Kimihide Nakamura – 20 September 2004 – The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH). Seven patients with both NASH and hypertension were treated with losartan (50 mg/d) for 48 weeks.

David C. Cronin, J. Michael Millis – 16 September 2004

Arie Regev, Enrique Molina, Rosana Moura, Pablo A. Bejarano, Amr Khaled, Phillip Ruiz, Kris Arheart, Mariana Berho, Cinthia B. Drachenberg, Patricia Mendez, Christopher O'Brien, Lennox Jeffers, Andreas Tzakis, Eugene R. Schiff – 16 September 2004 – Histopathologic assessment is considered essential for the differentiation of recurrent hepatitis C (RHC) from acute cellular rejection (ACR) after liver transplantation (LT); however, there is limited information regarding its reliability.

Peter L. Abt, Rachel Rapaport‐Kelz, Niraj M. Desai, Adam Frank, Seema Sonnad, Elizabeth Rand, James F. Markmann, Abraham Shaked, Kim M. Olthoff – 16 September 2004 – Segmental liver transplantation with living donor (LD), reduced cadaveric (Reduced), and split cadaveric (Split) allografts has expanded the availability of size‐appropriate organs for pediatric recipients. The relevance of recipient age to the selection of graft type has not been fully explored, but could offer the potential to maximize recipient outcome and donor utilization.

Paul Martin, Ronald W. Busuttil, Robert M. Goldstein, Jeffrey S. Crippin, Goran B. Klintmalm, William E. Fitzsimmons, Carol Uleman – 16 September 2004 – Hepatitis C virus (HCV)‐induced cirrhosis is the commonest indication for orthotopic liver transplantation, but HCV recurrence is nearly universal and may worsen patient / graft outcomes. The frequency and severity of HCV recurrence has apparently increased in recent years, raising concern about a possible role for newer immunosuppression regimens in this increase, including potentially tacrolimus.

Todd A. Sheer, Bruce A. Runyon – 16 September 2004

Norman M. Kneteman, José Oberholzer, Mohammed Al Saghier, Glenda A. Meeberg, Maurice Blitz, Mang M. Ma, Winnie W.S. Wong, Klaus Gutfreund, Andrew L. Mason, Larry D. Jewell, A.M. James Shapiro, Vincent G. Bain, David L. Bigam – 16 September 2004 – An increasing number of patients with hepatocellular carcinoma (HCC) are undergoing evaluation for listing for liver transplantation. Criteria for selection require ongoing review for suitability.

Margarita Sala, Josep Fuster, Josep M. Llovet, Miquel Navasa, Manel Solé, María Varela, Fernando Pons, Antoni Rimola, Juan Carlos García‐Valdecasas, Concepció Brú, Jordi Bruix – 16 September 2004 – Surgical resection and liver transplantation offer a 5‐year survival greater than 70% in patients with hepatocellular carcinoma, but the high recurrence rate impairs long‐term outcome after resection. Pathological data such as vascular invasion and detection of additional nodules predict recurrence and divide patients into high and low risk profile.