Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation

Paul J. Thuluvath, Hwan Y. Yoo – 16 September 2004 – Live donor liver transplantation (LDLT) has become increasingly common in the United States and around the world. In this study, we compared the outcome of 764 patients who received LDLT in the United States and compared the results with a matched population that received deceased donor transplantation (DDLT) using the United Network for Organ Sharing (UNOS) database.

High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: An indication for salvage liver transplantation

Margarita Sala, Josep Fuster, Josep M. Llovet, Miquel Navasa, Manel Solé, María Varela, Fernando Pons, Antoni Rimola, Juan Carlos García‐Valdecasas, Concepció Brú, Jordi Bruix – 16 September 2004 – Surgical resection and liver transplantation offer a 5‐year survival greater than 70% in patients with hepatocellular carcinoma, but the high recurrence rate impairs long‐term outcome after resection. Pathological data such as vascular invasion and detection of additional nodules predict recurrence and divide patients into high and low risk profile.

Sirolimus‐based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma

Norman M. Kneteman, José Oberholzer, Mohammed Al Saghier, Glenda A. Meeberg, Maurice Blitz, Mang M. Ma, Winnie W.S. Wong, Klaus Gutfreund, Andrew L. Mason, Larry D. Jewell, A.M. James Shapiro, Vincent G. Bain, David L. Bigam – 16 September 2004 – An increasing number of patients with hepatocellular carcinoma (HCC) are undergoing evaluation for listing for liver transplantation. Criteria for selection require ongoing review for suitability.

Impact of tacrolimus versus cyclosporine in hepatitis C virus‐infected liver transplant recipients on recurrent hepatitis: A prospective, randomized trial

Paul Martin, Ronald W. Busuttil, Robert M. Goldstein, Jeffrey S. Crippin, Goran B. Klintmalm, William E. Fitzsimmons, Carol Uleman – 16 September 2004 – Hepatitis C virus (HCV)‐induced cirrhosis is the commonest indication for orthotopic liver transplantation, but HCV recurrence is nearly universal and may worsen patient / graft outcomes. The frequency and severity of HCV recurrence has apparently increased in recent years, raising concern about a possible role for newer immunosuppression regimens in this increase, including potentially tacrolimus.

Survival among pediatric liver transplant recipients: Impact of segmental grafts

Peter L. Abt, Rachel Rapaport‐Kelz, Niraj M. Desai, Adam Frank, Seema Sonnad, Elizabeth Rand, James F. Markmann, Abraham Shaked, Kim M. Olthoff – 16 September 2004 – Segmental liver transplantation with living donor (LD), reduced cadaveric (Reduced), and split cadaveric (Split) allografts has expanded the availability of size‐appropriate organs for pediatric recipients. The relevance of recipient age to the selection of graft type has not been fully explored, but could offer the potential to maximize recipient outcome and donor utilization.

Reliability of histopathologic assessment for the differentiation of recurrent hepatitis C from acute rejection after liver transplantation

Arie Regev, Enrique Molina, Rosana Moura, Pablo A. Bejarano, Amr Khaled, Phillip Ruiz, Kris Arheart, Mariana Berho, Cinthia B. Drachenberg, Patricia Mendez, Christopher O'Brien, Lennox Jeffers, Andreas Tzakis, Eugene R. Schiff – 16 September 2004 – Histopathologic assessment is considered essential for the differentiation of recurrent hepatitis C (RHC) from acute cellular rejection (ACR) after liver transplantation (LT); however, there is limited information regarding its reliability.

Increased prothrombin time and platelet counts in living donor right hepatectomy: Implications for epidural anesthesia

Antonio Siniscalchi, Bruno Begliomini, Lesley De Pietri, Vanessa Braglia, Matteo Gazzi, Michele Masetti, Fabrizio Di Benedetto, Antonio D. Pinna, Charles M. Miller, Alberto Pasetto – 30 August 2004 – The risks and benefits of adult‐to‐adult living donor liver transplantation need to be carefully evaluated. Anesthetic management includes postoperative epidural pain relief; however, even patients with a normal preoperative coagulation profile may suffer transient postoperative coagulation derangement.

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