David Brandhagen – 30 August 2004 – We observed the development of phenotypic hereditary haemochromatosis in a non‐hereditary haemochromatosis liver transplant recipient, following transplantation with a liver from a C282Y heterozygous donor. No cause for secondary iron overload was identified. Subsequent sequencing of the HFE gene of both donor and recipient revealed a strong candidate for a novel pathogenic HFE mutation.

Yoji Kishi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Yuichi Matsui, Norihiro Kokudo, Masatoshi Makuuchi – 30 August 2004 – There are few reported techniques to minimize the congestion in the donor after left liver graft procuring. If a large tributary of the middle hepatic vein (MHV) draining segment VIII (V8) converges into the root of the MHV in a donor of left liver, this branch should be preserved on the donor side. The volume of congested area when the V8 was ligated was predicted preoperatively by computed tomography (CT) and examined intraoperatively by the clamp test.

Sambit Sen, Nathan A. Davies, Rajeshwar P. Mookerjee, Lisa M. Cheshire, Stephen J. Hodges, Roger Williams, Rajiv Jalan – 30 August 2004 – The pathophysiological basis of acute‐on‐chronic liver failure (ACLF) is unclear but systemic inflammatory response is thought to be important. In patients with ACLF, the molecular adsorbents recirculating system (MARS) improves individual organ function, but the effect of MARS on the proposed mediators of systemic inflammatory response is unclear.

Xian Liang Li, Kwan Man, Kevin T. Ng, Terence K. Lee, Chung Mau Lo, Sheung Tat Fan – 30 August 2004 – Ischemia / reperfusion (I / R) injury is related to tissue graft energy status. Insulin, which is currently used in the University of Wisconsin (UW) preservation solution with insulin (UWI), is an anabolic hormone and was shown to exacerbate the hepatic I / R injury in our previous study. In this study, the energy status and regulation of metabolism genes by insulin were investigated in liver grafts preserved by UW solution.

Aparna Venkatraman, Sruti Shiva, Amanda Wigley, Elena Ulasova, David Chhieng, Shannon M. Bailey, Victor M. Darley‐Usmar – 30 August 2004 – Nitric oxide (NO) is now known to control both mitochondrial respiration and organelle biogenesis. Under conditions of ethanol‐dependent hepatic dysfunction, steatosis is increased, and this is associated with increased expression of inducible nitric oxide synthase (iNOS).

Nicolas Carbonell, Arnaud Pauwels, Lawrence Serfaty, Olivier Fourdan, Victor George Lévy, Raoul Poupon – 30 August 2004 – Over the past two decades, new treatment modalities have been introduced for the management of variceal bleeding. The aim of this retrospective study in a single center was to assess whether these treatments have improved the prognosis for cirrhotic patients with variceal bleeding. We reviewed the clinical records of all patients with cirrhosis admitted to our Liver Intensive Care Unit due to variceal bleeding during the years 1980, 1985, 1990, 1995, and 2000.

Montserrat Garcia‐Retortillo, Xavier Forns, Josep M. Llovet, Miquel Navasa, Anna Feliu, Anna Massaguer, Miquel Bruguera, Josep Fuster, Juan Carlos Garcia‐Valdecasas, Antoni Rimola – 30 August 2004 – Preliminary reports suggested that hepatitis C virus (HCV) infection has a more aggressive course following living donor liver transplantation (LDLT) compared to cadaveric liver transplantation (CLT). The aim of this prospective study was to establish if HCV disease recurrence differs between LDLT and CLT.

Masao Omata – 30 August 2004

Lennox J. Jeffers, William Cassidy, Charles D. Howell, Sylvia Hu, K. Rajender Reddy – 30 August 2004

Konrad L. Streetz, Torsten Wuestefeld, Michael P. Manns, Christian Trautwein – 30 August 2004