Selective priming to Toll‐like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up‐regulation of MD‐2 in mice

Laszlo Romics, Angela Dolganiuc, Karen Kodys, Yvonne Drechsler, Shilpa Oak, Arumugam Velayudham, Pranoti Mandrekar, Gyongyi Szabo – 30 August 2004 – Lipopolysaccharide (LPS) triggers cytokine production through Toll‐like receptor 4 (TLR4), which shares downstream signaling pathways with TLR2. We investigated the roles of TLR2 and TLR4 in Propionibacterium acnes (P. acnes)–primed, LPS‐induced liver damage using selective TLR ligands. Stock LPS induced interleukin 8 in both TLR4‐ and TLR2‐expressing human embryonic kidney (HEK) 293 cells.

Long‐term results and modeling to predict outcomes in recipients with HCV infection: Results of the NIDDK liver transplantation database

Michael Charlton, Kris Ruppert, Steven H. Belle, Nathan Bass, Daniel Schafer, Russell H. Wiesner, Katherine Detre, Yuling Wei, James Everhart – 30 August 2004 – Hepatitis C virus (HCV)‐associated liver disease is the most common indication for liver transplantation (LT). There are, however, no long‐term (>5 year) studies of comparative outcomes for recipients with HCV infection, and no models capable of identifying recipients with HCV infection at greatest risk for adverse outcomes.

Donor selection for procurement of right posterior segment graft in living donor liver transplantation

Shin Hwang, Sung‐Gyu Lee, Young‐Joo Lee, Kwang‐Min Park, Ki‐Hun Kim, Chul‐Soo Ahn, Kyu‐Bo Sung, Deok‐Bog Moon, Tae‐Yong Ha, Keon‐Kuk Kim, Yeon‐Dae Kim – 30 August 2004 – The right posterior segment (RPS) graft was introduced to overcome graft‐size mismatch when the donor liver demonstrates a disproportionately small left lobe (LL). As variants of liver anatomy seemed to be related to the feasibility of RPS graft procurement, in 2003, we performed a prospective study to assess its feasibility in 197 consecutive living donors.

Molecular adsorbent recirculating system for acute and acute‐on‐chronic liver failure: A meta‐analysis

Mohammed S. Khuroo, Mehnaaz S. Khuroo, Karim L.C. Farahat – 30 August 2004 – Molecular adsorbent recirculating system (MARS) is an important option for patients with liver failure to give them additional time for recovery or to serve as a “bridge” to transplantation. However, its effect on survival for such patients is not well known. Our aim was to assess the treatment effects of MARS on patients with acute and acute‐on‐chronic liver failure. The outcomes measure evaluated was survival.

Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation

Montserrat Garcia‐Retortillo, Xavier Forns, Josep M. Llovet, Miquel Navasa, Anna Feliu, Anna Massaguer, Miquel Bruguera, Josep Fuster, Juan Carlos Garcia‐Valdecasas, Antoni Rimola – 30 August 2004 – Preliminary reports suggested that hepatitis C virus (HCV) infection has a more aggressive course following living donor liver transplantation (LDLT) compared to cadaveric liver transplantation (CLT). The aim of this prospective study was to establish if HCV disease recurrence differs between LDLT and CLT.

Improved survival after variceal bleeding in patients with cirrhosis over the past two decades

Nicolas Carbonell, Arnaud Pauwels, Lawrence Serfaty, Olivier Fourdan, Victor George Lévy, Raoul Poupon – 30 August 2004 – Over the past two decades, new treatment modalities have been introduced for the management of variceal bleeding. The aim of this retrospective study in a single center was to assess whether these treatments have improved the prognosis for cirrhotic patients with variceal bleeding. We reviewed the clinical records of all patients with cirrhosis admitted to our Liver Intensive Care Unit due to variceal bleeding during the years 1980, 1985, 1990, 1995, and 2000.

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