Reexamining the role of the humoral immune response in control of hepatitis C virus infection

Lynn B. Dustin – 30 August 2004 – Immunoglobulin GM and KM allotypes—genetic markers of γ and κ chains, respectively—are associated with immune responsiveness to several infectious pathogens and with survival in certain viral epidemics. We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV) infection. To test this hypothesis, we serologically allotyped 100 persons with well‐documented clearance of HCV infection and 198 matched persistently infected persons.

Role of the renin‐angiotensin system in hepatic ischemia reperfusion injury in rats

Luping Guo, Katharine S. Richardson, Lindsay M. Tucker, Mark A. Doll, David W. Hein, Gavin E. Arteel – 30 August 2004 – It has been shown that the renin‐angiotensin system (RAS) plays key roles in the development of fibrosis in numerous organs, including the liver. Other studies have suggested that the RAS also may play roles in diseases of chronic inflammation. However, whether the RAS also can mediate acute inflammation in liver is unclear.

Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome

Federico P. Gómez, Graciela Martínez‐Pallí, Joan A. Barberà, Josep Roca, Miquel Navasa, Robert Rodríguez‐Roisin – 30 August 2004 – The mechanism of orthodeoxia (OD), or decreased partial pressure of arterial oxygen (PaO2) from supine to upright, a characteristic feature of hepatopulmonary syndrome (HPS), has never been comprehensively elucidated.

Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients

Danny Ka‐Ho Wong, Man‐Fung Yuen, HeJun Yuan, Simon Siu‐Man Sum, Chee‐Kin Hui, Jeff Hall, Ching‐Lung Lai – 30 August 2004 – This study examined a signal amplification assay, the Invader assay, for the quantitation of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) in liver biopsies and sera. DNA was extracted from liver biopsy and serum samples were collected from 16 hepatitis B e antigen (HBeAg)‐positive and 36 antibody‐to‐HBeAg‐positive (anti–HBe‐positive) chronic hepatitis B patients. The amount of total HBV DNA and cccDNA was measured using the Invader assay.

Interleukin 1β inhibits CAR‐induced expression of hepatic genes involved in drug and bilirubin clearance

Eric Assenat, Sabine Gerbal‐Chaloin, Dominique Larrey, Jean Saric, Jean‐Michel Fabre, Patrick Maurel, Marie‐José Vilarem, Jean Marc Pascussi – 19 August 2004 – During the inflammatory response, intrahepatic cholestasis and decreased drug metabolism are frequently observed.

Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates

Anna Glantz, Hanns‐Ulrich Marschall, Lars‐Åke Mattsson – 13 August 2004 – Intrahepatic cholestasis of pregnancy (ICP), characterized by pruritus in the second half of pregnancy, entails an increased risk to the fetus. This study was designed to determine the incidence and fetal complication rates in ICP, and to define groups at increased risk.

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