Effect of high‐dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing cholangitis
Daniel Rost, Gerda Rudolph, Petra Kloeters‐Plachky, Adolf Stiehl – 30 August 2004 – Ursodeoxycholic acid (UDCA) has beneficial effects in cholestatic liver diseases. In primary sclerosing cholangitis (PSC), there is evidence that high doses (±20 mg/kg) of UDCA may be more effective than average doses. Biliary enrichment of UDCA at such high doses may represent the decisive factor for its beneficial effect.