Selective priming to Toll‐like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up‐regulation of MD‐2 in mice
Laszlo Romics, Angela Dolganiuc, Karen Kodys, Yvonne Drechsler, Shilpa Oak, Arumugam Velayudham, Pranoti Mandrekar, Gyongyi Szabo – 30 August 2004 – Lipopolysaccharide (LPS) triggers cytokine production through Toll‐like receptor 4 (TLR4), which shares downstream signaling pathways with TLR2. We investigated the roles of TLR2 and TLR4 in Propionibacterium acnes (P. acnes)–primed, LPS‐induced liver damage using selective TLR ligands. Stock LPS induced interleukin 8 in both TLR4‐ and TLR2‐expressing human embryonic kidney (HEK) 293 cells.