Anita Pathil, Sorin Armeanu, Sascha Venturelli, Paolo Mascagni, Thomas S. Weiss, Michael Gregor, Ulrich M. Lauer, Michael Bitzer – 22 February 2006 – Hepatocellular carcinoma (HCC) displays a striking resistance to chemotherapeutic drugs or innovative tumor cell apoptosis–inducing agents such as tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL). Recently, we found 2 histone deacetylase inhibitors (HDAC‐I), valproic acid and ITF2357, exhibiting inherent therapeutic activity against HCC.

Martin Stockmann, Thomas Konrad, Sabine Nolting, Diana Hünerbein, Klaus‐Dieter Wernecke, Helena Döbling, Thomas Steinmüller, Peter Neuhaus – 22 February 2006 – Controversial data exists concerning the impact of immunosuppressive therapy on the development of post‐transplantation diabetes mellitus (PTDM). Therefore, we investigated glucose metabolism in healthy donors and in recipients of living‐donor liver transplants (LD‐LTX, n=18) without pre‐existing diabetes mellitus before, on day 10, month 6, and month 12 after intervention.

Burton Combes, Scott S. Emerson – 22 February 2006

Elwyn Elias – 22 February 2006

Satdarshan P. S. Monga – 22 February 2006

Jayant A. Talwalkar, Konstantinos N. Lazaridis – 22 February 2006

Jessica Zucman‐Rossi, Emmanuelle Jeannot, Jeanne Tran Van Nhieu, Jean‐Yves Scoazec, Catherine Guettier, Sandra Rebouissou, Yannick Bacq, Emmanuelle Leteurtre, Valérie Paradis, Sophie Michalak, Dominique Wendum, Laurence Chiche, Monique Fabre, Lucille Mellottee, Christophe Laurent, Christian Partensky, Denis Castaing, Elie Serge Zafrani, Pierre Laurent‐Puig, Charles Balabaud, Paulette Bioulac‐Sage – 22 February 2006 – Hepatocellular adenomas are benign tumors that can be difficult to diagnose.

Takashi Kaizu, Atsushi Ikeda, Atsunori Nakao, Yoshihito Takahashi, Allan Tsung, Junichi Kohmoto, Hideyoshi Toyokawa, Lifang Shao, Brian T. Bucher, Koji Tomiyama, Michael A. Nalesnik, Noriko Murase, David A. Geller – 22 February 2006 – The exact role of inducible NOS (iNOS) in liver ischemia/reperfusion (I/R) injury is controversial. This study was designed to investigate whether donor liver pretreatment with adenovirus encoding iNOS (AdiNOS) ameliorates I/R injury associated with liver transplantation.

Zhaorui Lian, Jie Liu, Li Li, Xianxing Li, Marcy Clayton, Meng‐Chao Wu, Hong‐Yang Wang, Patrick Arbuthnot, Michael Kew, Daiming Fan, Mark A. Feitelson – 22 February 2006 – Intrahepatic expression of hepatitis B x antigen (HBxAg) is associated with the development of hepatocellular carcinoma (HCC), perhaps through trans‐activation of selected cellular genes. When this was examined by PowerBlot analysis, upregulated levels of β‐catenin and several known β‐catenin effectors were observed in HBxAg‐positive compared with HBxAg‐negative HepG2 cells.

Flavia Bortolotti, Maria Guido, Samuela Bartolacci, Paolo Cadrobbi, Carlo Crivellaro, Franco Noventa, Giulia Morsica, Maria Moriondo, Angelo Gatta – 22 February 2006 – Chronic hepatitis B is usually a benign disease in Caucasian children; however, the long‐term prognosis remains unsettled. This report describes the results of a 29‐year longitudinal study including 99 white children with chronic hepatitis B, mainly acquired horizontally: 91 were hepatitis B e antigen (HBeAg) positive (4 had cirrhosis), and 8 were HBeAg negative at presentation.