Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation

David P. Breen, Anthony M. Marinaki, Monica Arenas, Peter C. Hayes – 22 June 2005 – Azathioprine (AZA) is a thiopurine prodrug commonly used in triple‐immunosuppressive therapy following liver transplantation. Approximately 1 in 10 patients suffers side effects in response to the drug, the most problematic being bone marrow toxicity. There is evidence that polymorphisms in the genes encoding thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPase) predict adverse drug reactions to AZA therapy.

Systematic review and validation of prognostic models in liver transplantation

Matthew Jacob, James D. Lewsey, Carlos Sharpin, Alexander Gimson, Mohammed Rela, Jan H.P. van der Meulen – 22 June 2005 – A model that can accurately predict post–liver transplant mortality would be useful for clinical decision making, would help to provide patients with prognostic information, and would facilitate fair comparisons of surgical performance between transplant units.

Liver transplantation for cardiac failure in patients with hereditary hemorrhagic telangiectasia

Thierry Thevenot, Claire Vanlemmens, Vincent Di Martino, Marie‐Claude Becker, Pierre‐Olivier Denue, Bernadette Kantelip, Solange Bresson‐Hadni, Bruno Heyd, Georges Mantion, Jean‐Philippe Miguet – 22 June 2005 – Liver involvement in hereditary hemorrhagic telangiectasia may lead to high‐output cardiac failure. Few data have been reported on orthotopic liver transplantation (OLT) for these patients. In this paper, we describe two patients treated by OLT as a salvage procedure for cardiac failure, and we review literature on this subject.

Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma

Thomas Decaens, Françoise Roudot‐Thoraval, Solange Bresson‐Hadni, Carole Meyer, Jean Gugenheim, Francois Durand, Pierre‐Henri Bernard, Olivier Boillot, Karim Boudjema, Yvon Calmus, Jean Hardwigsen, Christian Ducerf, Georges Philippe Pageaux, Sebastien Dharancy, Olivier Chazouilleres, Daniel Dhumeaux, Daniel Cherqui, Christophe Duvoux – 22 June 2005 – The actual impact of transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient survival and HCC recurrence is not known.

“All‐in‐one” imaging protocols for the evaluation of potential living liver donors: Comparison of magnetic resonance imaging and multidetector computed tomography

Tobias Schroeder, Massimo Malagó, Jörg F. Debatin, Mathias Goyen, Silvio Nadalin, Stefan G. Ruehm – 22 June 2005 – In order to compare the performance of “all‐in‐one” magnetic resonance imaging (MRI) and “all‐in‐one” multidetector computed tomography (MDCT) in the preharvest evaluation 25 potential living donors underwent both MRI and MDCT. MRI was performed on a high‐performance 1.5‐T scanner, computed tomography (CT) on a 4‐row multidetector‐scanner. Both scan protocols included angiography of the arterial and venous hepatic systems.

Changes in oxyhemoglobin dissociation curve in intrabdominal organs during pig experimental orthotopic liver transplantation

Georgia Kostopanagiotou, Kassiani Theodoraki, Ageliki Pandazi, Nikolaos Arkadopoulos, Konstantinos Kostopanagiotou, Vassilios Smyrniotis – 22 June 2005 – Liver transplantation has become a gold standard treatment for irreversible liver disease. Conventional measures of oxygenation are inadequate to understand the dynamics of regional oxygen metabolism during liver transplantation because they represent global markers of tissue dysoxia.

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