Robert S. McCuskey, Yoshiya Ito, Graham R. Robertson, Margaret K. McCuskey, Michael Perry, Geoffrey C. Farrell – 13 August 2004 – In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear whether similar changes occur in other forms of steatohepatitis. We therefore examined whether hepatic microvascular dysfunction occurs in fibrosing steatohepatitis induced by feeding mice a high‐fat methionine‐ and choline‐deficient (MCD) diet.

Anna Glantz, Hanns‐Ulrich Marschall, Lars‐Åke Mattsson – 13 August 2004 – Intrahepatic cholestasis of pregnancy (ICP), characterized by pruritus in the second half of pregnancy, entails an increased risk to the fetus. This study was designed to determine the incidence and fetal complication rates in ICP, and to define groups at increased risk.

Robert S. Egerman, Caroline A. Riely – 13 August 2004

Vivian S. Lee, Glyn R. Morgan, Jennifer C. Lin, Carol A. Nazzaro, Jerry S. Chang, Lewis W. Teperman, Glenn A. Krinsky – 23 July 2004 – Our objective was to investigate the coexistence of vascular and biliary anatomic variants, the latter of which are known to increase the risk of biliary complications in living liver donor transplantation.

Mark W. Russo, Joseph A. Galanko, Roshan Shrestha, Michael W. Fried, Paul Watkins – 23 July 2004 – Studies of acute liver failure from drugs have included cases mostly attributed to acetaminophen (APAP) but have reported limited data on other drugs. We used the United Network for Organ Sharing (UNOS) liver transplant database from 1990 to 2002 to identify recipients and estimate a U.S. population‐based rate of liver transplantation due to acute liver failure from drugs. Patients were identified if their diagnosis was acute hepatic necrosis from an implicated drug at the time of transplant.

Ryan A. McTaggart, Norah A. Terrault, Andrew J. Vardanian, Alan Bostrom, Sandy Feng – 23 July 2004 – Although recurrent hepatitis C (HCV) occurs universally after liver transplantation (LT), its tempo and severity are variable and unpredictable. Diagnosis and treatment of early acute rejection (EAR) likely affect the course of recurrent HCV disease. We have studied a contemporary cohort of LT recipients to reexamine risk factors for EAR. We hypothesized that HCV etiology may represent a significant risk factor for EAR for many reasons.

Stefan A. Topp, Gundumi A. Upadhya, Steven M. Strasberg – 23 July 2004 – Cold preservation of rat sinusoidal endothelial cells causes actin disassembly, cell rounding, matrix metalloproteinase (MMP) secretion, and platelet adhesiveness. Studies in rats suggest that gelatinases MMP2 and MMP9 are the key mediators of the injury. We created a model of cold preservation injury in mouse sinusoidal endothelial cell (MSEC) to examine the effect of cold on MSEC, specifically on MSEC from genetically deleted mice (MMP9/KO) mice.

Uwe J.F. Tietge, Oliver Selberg, Andreas Kreter, Matthias J. Bahr, Matthias Pirlich, Wolfgang Burchert, Manfred J. Müller, Michael P. Manns, Klaus H.W. Böker – 23 July 2004 – With increasing long‐term survival rates after orthotopic liver transplantation (OLT), metabolic alterations complicating the clinical course, such as diabetes mellitus (DM), become increasingly important. Liver cirrhosis is associated with severe alterations in glucose metabolism. However, it is currently unclear whether these changes are reversed by successful OLT.

Gianni Biancofiore, Giorgio Della Rocca, Lucia Bindi, Anna Romanelli, Massimo Esposito, Luca Meacci, Lucio Urbani, Franco Filipponi, Franco Mosca – 23 July 2004 – With the aim of assessing whether fenoldopam can help to preserve renal function after liver transplantation, we randomized 140 consecutive recipients with comparable preoperative renal function to receive fenoldopam 0.1 μg/kg/minute (group F, 46 patients), dopamine 3 μg/kg/minute (group D, 48 patients), or placebo (group P, 46 patients) from the time of anesthesia induction to 96 hours postoperatively.

Zu‐hua Gao, Vivian C. McAlister, James R. Wright, Chloe C. McAlister, Kevork Peltekian, Allan S. MacDonald – 23 July 2004 – Outcomes may differ after kidney transplantation compared to combined liver‐kidney transplantation. In animal models, distinct patterns of antidonor immunoglobulin (Ig) G subclasses are associated with either rejection or transplant tolerance. Flow cytometry has increased the sensitivity of antidonor immunoglobulin detection. We compared antidonor IgG subclass responses in kidney transplant recipients to those in recipients of liver or multiorgan grafts.