C/EBP β isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver

Tom Luedde, Moritz Duderstadt, Konrad L. Streetz, Frank Tacke, Stefan Kubicka, Michael P. Manns, Christian Trautwein – 13 August 2004 – The CCAAT enhancer‐binding protein (C/EBP) β gene can produce several N‐terminally truncated isoforms. Liver‐enriched activator protein (LAP) is a transcriptional activator in many systems, whereas liver‐enriched inhibitory protein (LIP) is regarded as a functional LAP antagonist. In this study, we examined the impact of these two proteins on cell cycle progression in the regenerating liver.

Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice

Robert S. McCuskey, Yoshiya Ito, Graham R. Robertson, Margaret K. McCuskey, Michael Perry, Geoffrey C. Farrell – 13 August 2004 – In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear whether similar changes occur in other forms of steatohepatitis. We therefore examined whether hepatic microvascular dysfunction occurs in fibrosing steatohepatitis induced by feeding mice a high‐fat methionine‐ and choline‐deficient (MCD) diet.

Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates

Anna Glantz, Hanns‐Ulrich Marschall, Lars‐Åke Mattsson – 13 August 2004 – Intrahepatic cholestasis of pregnancy (ICP), characterized by pruritus in the second half of pregnancy, entails an increased risk to the fetus. This study was designed to determine the incidence and fetal complication rates in ICP, and to define groups at increased risk.

Liver transplant donor candidates: Associations between vascular and biliary anatomic variants

Vivian S. Lee, Glyn R. Morgan, Jennifer C. Lin, Carol A. Nazzaro, Jerry S. Chang, Lewis W. Teperman, Glenn A. Krinsky – 23 July 2004 – Our objective was to investigate the coexistence of vascular and biliary anatomic variants, the latter of which are known to increase the risk of biliary complications in living liver donor transplantation.

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