Orthotopic liver transplantation for portosystemic encephalopathy in an adult with congenital absence of the portal vein

Maciej Wojcicki, Elizabeth B. Haagsma, Annette S.H. Gouw, Maarten J.H. Slooff, Robert J. Porte – 30 August 2004 – Congenital absence of the portal vein (CAPV) is a very rare venous malformation in which mesenteric venous blood drains directly into the systemic circulation. There is no portal perfusion of the liver and no portal hypertension. This abnormality is usually coincidentally discovered in children, the majority of whom have no signs of encephalopathy and only slightly abnormal liver function tests.

Increased prothrombin time and platelet counts in living donor right hepatectomy: Implications for epidural anesthesia

Antonio Siniscalchi, Bruno Begliomini, Lesley De Pietri, Vanessa Braglia, Matteo Gazzi, Michele Masetti, Fabrizio Di Benedetto, Antonio D. Pinna, Charles M. Miller, Alberto Pasetto – 30 August 2004 – The risks and benefits of adult‐to‐adult living donor liver transplantation need to be carefully evaluated. Anesthetic management includes postoperative epidural pain relief; however, even patients with a normal preoperative coagulation profile may suffer transient postoperative coagulation derangement.

Interleukin 1β inhibits CAR‐induced expression of hepatic genes involved in drug and bilirubin clearance

Eric Assenat, Sabine Gerbal‐Chaloin, Dominique Larrey, Jean Saric, Jean‐Michel Fabre, Patrick Maurel, Marie‐José Vilarem, Jean Marc Pascussi – 19 August 2004 – During the inflammatory response, intrahepatic cholestasis and decreased drug metabolism are frequently observed.

Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease

Anne M. Wertheimer, Antony Bakke, Hugo R. Rosen – 13 August 2004 – Chronic liver disease has been shown to be associated with diminished humoral and cellular immune function. Although antigen‐presenting cells (APC) that initiate immune responses include various cells (B cells, endothelial cells, macrophages, etc.), the dendritic cell (DC) is a professional APC that activates naive T cells most efficiently.

Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease

Gary A. Abrams, Sachin S. Kunde, Audrey J. Lazenby, Ronald H. Clements – 13 August 2004 – Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that can lead to hepatic fibrosis and cirrhosis. Portal fibrosis in the absence of NASH, called isolated portal fibrosis (IPF), has received less attention and has not been classified as a spectrum of NAFLD.

Novel peptide‐based vaccines efficiently prime murine “help”‐independent CD8+ T cell responses in the liver

Nektarios Dikopoulos, Petra Riedl, Reinhold Schirmbeck, Jörg Reimann – 13 August 2004 – Vaccines for the prophylactic and/or therapeutic immunization against hepatotropic pathogens (e.g., hepatitis B and hepatitis C virus) should establish long‐lasting, specific antiviral effector/memory CD8+ T cell immunity in the liver. We describe a novel peptide‐based vaccine in which antigenic major histocompatibility complex Class I–binding peptides are fused to a cationic (e.g., human immunodeficiency virus tat‐derived) domain and complexed to immune‐stimulating oligonucleotides.

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