Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice

Robert S. McCuskey, Yoshiya Ito, Graham R. Robertson, Margaret K. McCuskey, Michael Perry, Geoffrey C. Farrell – 13 August 2004 – In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear whether similar changes occur in other forms of steatohepatitis. We therefore examined whether hepatic microvascular dysfunction occurs in fibrosing steatohepatitis induced by feeding mice a high‐fat methionine‐ and choline‐deficient (MCD) diet.

C/EBP β isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver

Tom Luedde, Moritz Duderstadt, Konrad L. Streetz, Frank Tacke, Stefan Kubicka, Michael P. Manns, Christian Trautwein – 13 August 2004 – The CCAAT enhancer‐binding protein (C/EBP) β gene can produce several N‐terminally truncated isoforms. Liver‐enriched activator protein (LAP) is a transcriptional activator in many systems, whereas liver‐enriched inhibitory protein (LIP) is regarded as a functional LAP antagonist. In this study, we examined the impact of these two proteins on cell cycle progression in the regenerating liver.

Association of estrogen receptor α polymorphisms with susceptibility to chronic hepatitis B virus infection

Guohong Deng, Gangqiao Zhou, Yun Zhai, Shuqing Li, Xuhong Li, Ya Li, Ruifang Zhang, Zhijian Yao, Yan Shen, Boqing Qiang, Yuming Wang, Fuchu He – 13 August 2004 – Several studies have demonstrated that estrogen receptor α (ESR1) participates in the pathogenesis of persistent hepatitis B virus (HBV) infection. To examine whether polymorphisms at the ESR1 gene locus are associated with persistent HBV infection, we resequenced ESR1 genomic region for single nucleotide polymorphisms (SNPs) in 27 unrelated Chinese.

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