The role of iNOS in alcohol‐dependent hepatotoxicity and mitochondrial dysfunction in mice

Aparna Venkatraman, Sruti Shiva, Amanda Wigley, Elena Ulasova, David Chhieng, Shannon M. Bailey, Victor M. Darley‐Usmar – 30 August 2004 – Nitric oxide (NO) is now known to control both mitochondrial respiration and organelle biogenesis. Under conditions of ethanol‐dependent hepatic dysfunction, steatosis is increased, and this is associated with increased expression of inducible nitric oxide synthase (iNOS).

Insulin in UW solution exacerbates hepatic ischemia / reperfusion injury by energy depletion through the IRS‐2 / SREBP‐1c pathway

Xian Liang Li, Kwan Man, Kevin T. Ng, Terence K. Lee, Chung Mau Lo, Sheung Tat Fan – 30 August 2004 – Ischemia / reperfusion (I / R) injury is related to tissue graft energy status. Insulin, which is currently used in the University of Wisconsin (UW) preservation solution with insulin (UWI), is an anabolic hormone and was shown to exacerbate the hepatic I / R injury in our previous study. In this study, the energy status and regulation of metabolism genes by insulin were investigated in liver grafts preserved by UW solution.

Pathophysiological effects of albumin dialysis in acute‐on‐chronic liver failure: A randomized controlled study

Sambit Sen, Nathan A. Davies, Rajeshwar P. Mookerjee, Lisa M. Cheshire, Stephen J. Hodges, Roger Williams, Rajiv Jalan – 30 August 2004 – The pathophysiological basis of acute‐on‐chronic liver failure (ACLF) is unclear but systemic inflammatory response is thought to be important. In patients with ACLF, the molecular adsorbents recirculating system (MARS) improves individual organ function, but the effect of MARS on the proposed mediators of systemic inflammatory response is unclear.

Sharing the middle hepatic vein between donor and recipient: Left liver graft procurement preserving a large segment VIII branch in donor

Yoji Kishi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Yuichi Matsui, Norihiro Kokudo, Masatoshi Makuuchi – 30 August 2004 – There are few reported techniques to minimize the congestion in the donor after left liver graft procuring. If a large tributary of the middle hepatic vein (MHV) draining segment VIII (V8) converges into the root of the MHV in a donor of left liver, this branch should be preserved on the donor side. The volume of congested area when the V8 was ligated was predicted preoperatively by computed tomography (CT) and examined intraoperatively by the clamp test.

Can liver transplantation improve our understanding of the pathophysiology of iron overload?

David Brandhagen – 30 August 2004 – We observed the development of phenotypic hereditary haemochromatosis in a non‐hereditary haemochromatosis liver transplant recipient, following transplantation with a liver from a C282Y heterozygous donor. No cause for secondary iron overload was identified. Subsequent sequencing of the HFE gene of both donor and recipient revealed a strong candidate for a novel pathogenic HFE mutation.

Effects of contrast media on renal function in patients with cirrhosis: A prospective study

Mònica Guevara, Glòria Fernández‐Esparrach, Carlo Alessandria, Aldo Torre, Carlos Terra, Xavier Montañà, Carlos Piera, Maria Luisa Alvarez, Wladimiro Jiménez, Pere Ginès, Vicente Arroyo – 30 August 2004 – Patients with cirrhosis are frequently submitted to radiological procedures that require the administration of contrast media. Contrast media is a well‐known cause of renal failure, particularly in the presence of some predisposing conditions. However, it is not known whether cirrhosis constitutes a risk factor for contrast media–induced renal failure.

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