Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
Robert S. McCuskey, Yoshiya Ito, Graham R. Robertson, Margaret K. McCuskey, Michael Perry, Geoffrey C. Farrell – 13 August 2004 – In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear whether similar changes occur in other forms of steatohepatitis. We therefore examined whether hepatic microvascular dysfunction occurs in fibrosing steatohepatitis induced by feeding mice a high‐fat methionine‐ and choline‐deficient (MCD) diet.