Risk of diabetes in HIV infected veterans pre‐ and post‐HAART and the role of HCV coinfection

Adeel A. Butt, Shawn L. Fultz, C. Kent Kwoh, David Kelley, Melissa Skanderson, Amy C. Justice – 30 June 2004 – We examined the association of hepatitis C virus (HCV) infection with diabetes in veterans infected with human immunodeficiency virus (HIV) before and after the institution of highly active antiretroviral therapy (HAART). The role of age, race, liver disease, alcohol, and drug diagnoses upon the risk of diabetes was also determined. Male veterans with HIV who entered care between 1992 and 2001 were identified from the Veterans Affairs (VA) administrative database.

Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation

R. Todd Stravitz, Mitchell L. Shiffman, Arun J. Sanyal, Velimir A. Luketic, Richard K. Sterling, Douglas M. Heuman, April Ashworth, A. Scott Mills, Melissa Contos, Adrian H. Cotterell, Daniel Maluf, Marc P. Posner, Robert A. Fisher – 29 June 2004 – Recurrent hepatitis C after liver transplantation remains a significant cause of graft loss and retransplantation.

Survival after liver transplantation in the United States: A disease‐specific analysis of the UNOS database

Mark S. Roberts, Derek C. Angus, Cindy L. Bryce, Zdenek Valenta, Lisa Weissfeld – 29 June 2004 – Our goal was to describe disease‐specific survival and the clinical variables that predict survival in a large national cohort of adult liver transplant recipients. Data on 17,044 adult patients who received an initial orthotopic liver transplant between 1990 and 1996 with follow‐up through 1999 was obtained from the United Network for Organ Sharing (UNOS).

A comparison of disease severity and survival rates after liver transplantation in the United Kingdom, Canada, and the United States

David A. Stell, Vivian C. McAlister, Douglas Thorburn – 29 June 2004 – The severity of preoperative liver disease influences the outcome of liver transplantation, is commonly used to determine priority on liver transplant waiting lists, and may differ between countries with different rates of liver disease and organ allocation systems. We compared the relative severity of liver disease in transplant recipients with chronic liver disease in the United States, Canada, and the United Kingdom and its relation to outcome.

Disparity in use of orthotopic liver transplantation among blacks and whites

Andrea E. Reid, Maria Resnick, YuChiao Chang, Nathan Buerstatte, Joel S. Weissman – 29 June 2004 – Orthotopic liver transplantation (OLT) is the best treatment for end‐stage liver disease. Limited data exist on the access of minorities to OLT. The aim of this study was to determine whether disparities exist among black and white OLT patients. Data were collected from the United Network for Organ Sharing on black and white 18–70 year‐old OLT waiting list registrants (n = 29,013) and OLT recipients (n = 15,805) between 1994 and 1998.

The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: A systematic review and meta‐analysis

Nasia Safdar, Adnan Said, Michael R. Lucey – 29 June 2004 – Selective digestive decontamination (SDD) refers to the use of antimicrobials to reduce the burden of aerobic gram‐negative bacteria and/or yeast in the intestinal tract to prevent infections caused by these organisms. Liver transplant patients are highly vulnerable to bacterial infection particularly with gram‐negative organisms within the first month after transplantation, and SDD has been proposed as a potential measure to prevent these infections. However, the benefit of this procedure remains controversial.

Bile duct strictures after adult liver transplantation: A role for biliary reconstructive surgery?

Robert Sutcliffe, Donal Maguire, Andrej Mróz, Bernard Portmann, John O'Grady, Matthew Bowles, Paolo Muiesan, Mohamed Rela, Nigel Heaton – 29 June 2004 – There is no accurate method to determine the functional significance of bile duct strictures after liver transplantation, and although biliary reconstructive surgery (Roux‐en‐Y hepaticojejunostomy, HJ) is the second‐line treatment in patients with persistent allograft dysfunction following failed endoscopic therapy, there is no evidence to support this approach.

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