Raúl J. Andrade, M. Isabel Lucena, Anabel Alonso, Miren García‐Cort́es, Elena García‐Ruiz, Rafael Benitez, M. Carmen Fernández, Gloria Pelaez, Manuel Romero, Raquel Corpas, José Antonio Durán, Manuel Jiménez, Luis Rodrigo, Flor Nogueras, Rafael Martín‐Vivaldi, José María Navarro, Javier Salmerón, Felipe Sánchez de la Cuesta, Ramón Hidalgo – 27 May 2004 – Drug‐induced idiosyncratic liver disease (DIILD) depends largely on host susceptibility factors. Small studies support the genetic influence of human leukocyte antigen (HLA) class II molecules on the predisposition to DIILD.

Adrian Reuben – 27 May 2004

Elisabetta Bugianesi, Giulio Marchesini – 27 May 2004

Albert J. Czaja, Herschel A. Carpenter – 27 May 2004 – Hepatic fibrosis and cirrhosis are possible consequences of corticosteroid‐treated autoimmune hepatitis. Our aims were to determine the frequency of progressive fibrosis and the factors associated with this progression. Two hundred seventy‐seven liver tissue specimens that had been obtained from 73 patients were interpreted in batch under code by a single pathologist.

Veronica Bordoni, Tonino Alonzi, Chiara Agrati, Fabrizio Poccia, Giovanna Borsellino, Giorgio Mancino, Gian Maria Fimia, Mauro Piacentini, Antonio Fantoni, Marco Tripodi – 27 May 2004 – While fetal liver is a major hematopoietic organ, normal adult liver provides a suitable microenvironment for a variety of immune cells and, in several pathological conditions, may become a site of extramedullary hematopoiesis. The direct influence of hepatocytes on hematopoietic cell differentiation is poorly understood.

Keith A. Delman, Jonathan S. Zager, Amit Bhargava, Henrik Petrowsky, Sandeep Malhotra, Michael I. Ebright, Joseph J. Bennett, Niraj J. Gusani, David A. Kooby, Gretchen D. Roberts, Yuman Fong – 27 May 2004 – Replication‐competent herpes simplex oncolytic viruses are promising anticancer agents that partly target increased DNA synthesis in tumor cells. Investigators have proposed that these DNA viruses may be combined with liver resection to enhance killing of liver malignancies.

Juan Carlos Garcia‐Pagán, Jaume Bosch – 27 May 2004

Marieke H. Schoemaker, Laura Conde de la Rosa, Manon Buist‐Homan, Titia E. Vrenken, Rick Havinga, Klaas Poelstra, Hidde J. Haisma, Peter L. M. Jansen, Han Moshage – 27 May 2004 – Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, but its mechanism of action is not yet well defined. The aim of this study was to explore the protective mechanisms of the taurine‐conjugate of UDCA (tauroursodeoxycholic acid [TUDCA]) against glycochenodeoxycholic acid (GCDCA)‐induced apoptosis in primary cultures of rat hepatocytes.

Yiqun Ling, Junlan Zhang, Bao Luo, Daisheng Song, Lichuan Liu, Liping Tang, Cecil R. Stockard, William E. Grizzle, David D. Ku, Michael B. Fallon – 27 May 2004 – Endothelin‐1 (ET‐1) stimulation of endothelial nitric oxide synthase (eNOS) via pulmonary endothelial endothelin B (ETB) receptors and pulmonary intravascular macrophage accumulation with expression of inducible nitric oxide synthase (iNOS) and heme oxygenase‐1 (HO‐1) are implicated in experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL).

Christoph Jüngst, Bin Cheng, Ralph Gehrke, Volker Schmitz, Hans Dieter Nischalke, Jan Ramakers, Peter Schramel, Peter Schirmacher, Tilman Sauerbruch, Wolfgang Helmut Caselmann – 27 May 2004 – Accumulation of genetic alterations in hepatocarcinogenesis is closely associated with chronic inflammatory liver disease. 8‐oxo‐2′‐deoxyguanosine (8‐oxo‐dG), the major promutagenic DNA adduct caused by reactive oxygen species (ROS), leads to G:C → T:A transversions.