Jeffrey S. Glenn – 27 May 2004 – Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral replication is unclear. We report that HCV RNA replication and assembly of the viral replication complex require geranylgeranylation of one or more host proteins.
John B. Dixon, Prithi S. Bhathal, Norman R. Hughes, Paul E. O'Brien – 27 May 2004 – The effect of significant weight loss on nonalcoholic fatty liver disease remains unclear. In this case series of 36 selected obese patients, we examined the effect of weight loss on nonalcoholic fatty liver disease, including nonalcoholic steatohepatitis (NASH) and hepatic fibrosis. These 36 patients (11 males, 25 females) had paired liver biopsies, the first at the time of laparoscopic adjustable gastric band placement and the second after weight loss.
Jay H. Hoofnagle – 27 May 2004
Sanaa M. Kamal, Alaa Ismail, Camilla S. Graham, Qi He, Jens W. Rasenack, Thomas Peters, Ahmed A. Tawil, Jutta J. Fehr, Khalifa El Sayed Khalifa, Mahmoud M. Madwar, Margaret James Koziel – 27 May 2004 – Pegylated interferon α (PEG IFN‐α) improves sustained virological response rates in chronic hepatitis C, but neither its role in acute hepatitis C nor the biologic basis for its action has been defined.
Kris V. Kowdley – 27 May 2004
Man‐Young Cha, Chang‐Myeong Kim, Young‐Min Park, Wang‐Shick Ryu – 27 May 2004 – Wnt/β‐catenin signaling contributes to diverse cellular functions, such as Drosophila wing development and colon carcinogenesis. Recently, stabilizing mutations of β‐catenin, a hallmark of Wnt signaling, were documented in significant numbers of primary hepatocellular carcinomas (HCC). However, whether the β‐catenin mutation leads to the activation of Wnt/β‐catenin signaling in hepatoma cells has not been established.
Nelson Fausto – 27 May 2004
Amr M. El‐Gibaly, Claudia Scheuer, Michael D. Menger, Brigitte Vollmar – 27 May 2004 – Early graft dysfunction due to ischemia reperfusion injury remains a major clinical challenge in liver transplantation. Because apoptosis may contribute to graft dysfunction, we studied whether transient inhibition of p53 is capable of improving graft quality by reducing apoptotic cell death. Rat livers were harvested and stored for 24 hours or 48 hours in a 4°C solution containing either pifithrin‐α (PFT‐α), a specific p53‐inhibitor, or the vehicle dimethyl‐sulfoxide.
Fabrice Lainé, Claude Bendavid, Romain Moirand, Sabrina Tessier, Michèle Perrin, Anne Guillygomarc'h, Dominique Guyader, Emmanuelle Calon, Alain Renault, Pierre Brissot, Bruno Turlin, Yves Deugnier – 27 May 2004 – The aim of this study was to determine noninvasive predictive factors of significant liver fibrosis in patients with increased serum aminotransferases associated with features of metabolic syndrome (abdominal obesity, systemic hypertension, fasting hyperglycemia, and dyslipidemia). One hundred seventy‐three patients were prospectively examined, regardless of alcohol consumption.
Jessy Lardon, Saskia De Breuck, Ilse Rooman, Leentje Van Lommel, Mogens Kruhøffer, Torben Orntoft, Frans Schuit, Luc Bouwens – 27 May 2004 – Under certain experimental conditions, hepatocytes can arise in the pancreas. It has been suggested that the pancreas retains a source of hepatocyte progenitor cells. However, such cells have not been yet identified in the adult pancreas. We describe here the transdifferentiation of primary rat pancreatic exocrine cells into hepatocyte‐like cells during 5 days of tissue culture in the presence of dexamethasone (DX).