Yasuhiko Sugawara, Masatoshi Makuuchi – 20 May 2004 – In 1993, the Shinshu Group performed the first successful adult‐to‐adult living donor liver transplantation (LDLT). During the first 10 years of LDLT, many technical innovations have been reported. The major limitation of LDLT for adult recipients is the size of the graft. To overcome the problem, several graft types were designed, including left liver graft with caudate lobe, right liver, modified right liver, and right lateral sector and dual grafts.

Tania A. Roskams, Neil D. Theise, Charles Balabaud, Govind Bhagat, Prithi S. Bhathal, Paulette Bioulac‐Sage, Elizabeth M. Brunt, James M. Crawford, Heather A. Crosby, Valeer Desmet, Milton J. Finegold, Stephen A. Geller, Annette S.H. Gouw, Prodromos Hytiroglou, A.S. Knisely, Masamichi Kojiro, Jay H. Lefkowitch, Yasuni Nakanuma, John K. Olynyk, Young Nyun Park, Bernard Portmann, Romil Saxena, Peter J. Scheuer, Alastair J. Strain, Swan N. Thung, Ian R. Wanless, A.

Alessandro Zanetti, Maria Antonietta Casiraghi – 26 April 2004

26 April 2004

Paul C. Adams, Michael J. Arthur, Thomas D. Boyer, Laurie D. DeLeve, Adrian M. Di Bisceglie, Mark Hall, Theodore R. Levin, Dawn Provenzale, Leonard Seeff – 26 April 2004 – This report summarizes an AASLD Clinical Workshop that was presented at Digestive Diseases Week 2003 on screening in liver diseases. As newer diagnostic tests become available, many liver diseases and complications of liver disease can be detected at an early asymptomatic stage. In many cases, early detection can lead to earlier treatment and an improved outcome.

Flavia Bortolotti, Maria Guido, Lucia Zancan, Nadia Gussetti – 26 April 2004

Jason M. Hui, Geoffrey C. Farrell, James G. Kench, Jacob George – 26 April 2004

Guruprasad P. Aithal, Lesley Ramsay, Ann K. Daly, Nhareet Sonchit, Julian B. S. Leathart, Graeme Alexander, J. Gerald Kenna, John Caldwell, Christopher P. Day – 26 April 2004 – Diclofenac is a nonsteroidal anti‐inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear. The purpose of the present study was to explore the potential role played by the immune processes.

Jesús Medina, Alicia G. Arroyo, Francisco Sánchez‐Madrid, Ricardo Moreno‐Otero – 26 April 2004 – Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that characterize several chronic liver diseases of viral and autoimmune origin. As a consequence, new vascular structures are formed to provide oxygen and nutrients. Angiogenesis involves a tightly regulated network of cellular and molecular mechanisms that result in the formation of functional vessels.

Christopher E. P. Goldring, Neil R. Kitteringham, Robert Elsby, Laura E. Randle, Yuri N. Clement, Dominic P. Williams, Michael McMahon, John D. Hayes, Ken Itoh, Masayuki Yamamoto, B. Kevin Park – 26 April 2004 – The transcription factor NF‐E2‐related factor 2 (Nrf2) plays an essential role in the mammalian response to chemical and oxidative stress through induction of hepatic phase II detoxification enzymes and regulation of glutathione (GSH).