Zhen Fan Yang, Tung Yu Tsui, David W. Ho, Terence C. Tang, Sheung‐Tat Fan – 20 May 2004 – This study aims to clarify the role of heme oxygenase‐1 (HO‐1) in small‐for‐size liver transplantation. Transplantation was performed using 40% small‐for‐size or 100% whole liver grafts in rats. When no treatment was given, over‐expression of HO‐1 was detected predominantly in the small‐for‐size grafts at 6 hours after reperfusion as compared to whole grafts in both syngeneic and allogeneic combinations.

Hiroshi Imamura, Norihiko Kokudo, Yasuhiko Sugawara, Keiji Sano, Jun‐ichi Kaneko, Tadatoshi Takayama, Masatoshi Makuuchi – 20 May 2004 – While inflow occlusion techniques such as Pringle's maneuver are accepted methods of reducing bleeding without inducing liver injury during liver surgery, donor hepatectomy for living donor liver transplantation is currently performed without inflow occlusion for fear that injury to the graft may result.

Ronnie T. Poon, Sheung Tat Fan – 20 May 2004

Koo‐Jeong Kang, Jae Hwi Jang, Tae Jin Lim, Yuna Kang, Kwan Kyu Park, In Seon Lee, Pierre‐Alain Clavien – 20 May 2004 – We designed this experimental study to determine the optimal cycle for intermittent inflow occlusion during liver resection. A cycle of intermittent clamping (IC) for 15 minutes of ischemia followed by reperfusion for 5 minutes during liver resection is currently the most popular protocol used by experienced liver centers. As each period of reperfusion is associated with bleeding, longer periods of clamping would be advantageous.

Hee Chul Yu, Heecheon You, Ho Lee, Zhe‐Wu Jin, Jang Il Moon, Baik Hwan Cho – 20 May 2004 – The standard liver volume (LV) of a recipient is estimated in liver transplantation to determine the minimum LV necessary for the recipient. Simple linear formulas of LV estimation were developed for the Japanese and Caucasian populations. The present study examined the applicability of the reported formulas to the Korean population. Liver density (LD) was determined by analyzing 24 healthy livers.

Lei Guo, Xiao‐Kang Li, Shin Enosawa, Naoko Funeshima, Seiichi Suzuki, Hiromitsu Kimura, Yasuhiko Sugawara, Katsunari Tezuka, Masatoshi Makuuchi – 20 May 2004 – A member of the costimulatory molecule family, inducible costimulator (ICOS), is expressed on activated T cells and plays a critical role in their primary activation and cytokine production. ICOS is involved in different immune phenomena, such as Th1‐mediated autoimmune disease and graft rejection.

Michael Charlton – 20 May 2004

Tania A. Roskams, Neil D. Theise, Charles Balabaud, Govind Bhagat, Prithi S. Bhathal, Paulette Bioulac‐Sage, Elizabeth M. Brunt, James M. Crawford, Heather A. Crosby, Valeer Desmet, Milton J. Finegold, Stephen A. Geller, Annette S.H. Gouw, Prodromos Hytiroglou, A.S. Knisely, Masamichi Kojiro, Jay H. Lefkowitch, Yasuni Nakanuma, John K. Olynyk, Young Nyun Park, Bernard Portmann, Romil Saxena, Peter J. Scheuer, Alastair J. Strain, Swan N. Thung, Ian R. Wanless, A.

Emilia Ip, Geoff Farrell, Pauline Hall, Graham Robertson, Isabelle Leclercq – 26 April 2004 – Administration of a methionine and choline deficient (MCD) diet to rodents causes progressive fibrosing steatohepatitis pathologically similar to human metabolic steatohepatitis. We have previously shown that the peroxisome proliferator‐activated receptor‐α (PPARα) agonist, Wy‐14,643, prevented the development of MCD diet‐induced steatohepatitis. We have now tested whether Wy‐14,643 ameliorates established steatohepatitis and fibrosis.

Toshitaka Hoppo, Hideaki Fujii, Tetsuro Hirose, Kentaro Yasuchika, Hisaya Azuma, Shinji Baba, Masato Naito, Takafumi Machimoto, Iwao Ikai – 26 April 2004 – Previously, we reported a system to enrich mouse fetal hepatic progenitor cells (HPCs) by forming cell aggregates. In this study, we sorted two cell populations, CD49f+Thy1−CD45− cells (CD49f‐postive cells) and CD49f±Thy1+CD45− cells (Thy1‐positive cells), from the cell aggregates using a flow cytometer.