Cytotoxic T‐cell elimination during anti‐CD4–induced rat liver acceptance and rapid replacement of functional graft antigen–presenting cells
Kazuhiro Usui, Junzo Yamaguchi, Weili Gu, Takashi Kanematsu – 20 May 2004 – In previous studies, we showed that primed T cells were eliminated in long‐term survival Wistar Furth (WF) recipient rats with spontaneously accepted Lewis (LEW) liver graft and that the grafted liver lost the ability to elicit rejection reaction early after liver transplantation. We hypothesized that the same phenomenon may be observed in tolerant animals after immunosuppression in a rejector rat strain combination (WF→LEW).