Management of drug‐to‐drug interactions between cyclosporine A and the protease‐inhibitor lopinavir/ritonavir in liver‐transplanted HIV‐infected patients

Martin Vogel, Esther Voigt, Hans‐Christoph Michaelis, Thomas Sudhop, Martin Wolff, Andreas Türler, Tilman Sauerbruch, Jürgen Kurt Rockstroh, Ulrich Spengler – 29 June 2004 – Highly active antiretroviral therapy (HAART) has improved the life expectancy of HIV‐infected patients, allowing orthotopic liver transplantation as a reasonable treatment option for selected patients with terminal liver disease.

Bile duct strictures after adult liver transplantation: A role for biliary reconstructive surgery?

Robert Sutcliffe, Donal Maguire, Andrej Mróz, Bernard Portmann, John O'Grady, Matthew Bowles, Paolo Muiesan, Mohamed Rela, Nigel Heaton – 29 June 2004 – There is no accurate method to determine the functional significance of bile duct strictures after liver transplantation, and although biliary reconstructive surgery (Roux‐en‐Y hepaticojejunostomy, HJ) is the second‐line treatment in patients with persistent allograft dysfunction following failed endoscopic therapy, there is no evidence to support this approach.

The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: A systematic review and meta‐analysis

Nasia Safdar, Adnan Said, Michael R. Lucey – 29 June 2004 – Selective digestive decontamination (SDD) refers to the use of antimicrobials to reduce the burden of aerobic gram‐negative bacteria and/or yeast in the intestinal tract to prevent infections caused by these organisms. Liver transplant patients are highly vulnerable to bacterial infection particularly with gram‐negative organisms within the first month after transplantation, and SDD has been proposed as a potential measure to prevent these infections. However, the benefit of this procedure remains controversial.

Disparity in use of orthotopic liver transplantation among blacks and whites

Andrea E. Reid, Maria Resnick, YuChiao Chang, Nathan Buerstatte, Joel S. Weissman – 29 June 2004 – Orthotopic liver transplantation (OLT) is the best treatment for end‐stage liver disease. Limited data exist on the access of minorities to OLT. The aim of this study was to determine whether disparities exist among black and white OLT patients. Data were collected from the United Network for Organ Sharing on black and white 18–70 year‐old OLT waiting list registrants (n = 29,013) and OLT recipients (n = 15,805) between 1994 and 1998.

A comparison of disease severity and survival rates after liver transplantation in the United Kingdom, Canada, and the United States

David A. Stell, Vivian C. McAlister, Douglas Thorburn – 29 June 2004 – The severity of preoperative liver disease influences the outcome of liver transplantation, is commonly used to determine priority on liver transplant waiting lists, and may differ between countries with different rates of liver disease and organ allocation systems. We compared the relative severity of liver disease in transplant recipients with chronic liver disease in the United States, Canada, and the United Kingdom and its relation to outcome.

Survival after liver transplantation in the United States: A disease‐specific analysis of the UNOS database

Mark S. Roberts, Derek C. Angus, Cindy L. Bryce, Zdenek Valenta, Lisa Weissfeld – 29 June 2004 – Our goal was to describe disease‐specific survival and the clinical variables that predict survival in a large national cohort of adult liver transplant recipients. Data on 17,044 adult patients who received an initial orthotopic liver transplant between 1990 and 1996 with follow‐up through 1999 was obtained from the United Network for Organ Sharing (UNOS).

Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation

R. Todd Stravitz, Mitchell L. Shiffman, Arun J. Sanyal, Velimir A. Luketic, Richard K. Sterling, Douglas M. Heuman, April Ashworth, A. Scott Mills, Melissa Contos, Adrian H. Cotterell, Daniel Maluf, Marc P. Posner, Robert A. Fisher – 29 June 2004 – Recurrent hepatitis C after liver transplantation remains a significant cause of graft loss and retransplantation.

Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome

Florence Wong, Lavinia Pantea, Kenneth Sniderman – 2 June 2004 – Hepatorenal syndrome (HRS) is a functional renal disorder complicating decompensated cirrhosis. Treatments to date, except liver transplantation, have been able to improve but not normalize renal function. The aim of this study was to determine the efficacy of transjugular intrahepatic portosystemic stent shunt (TIPS) as a treatment for type 1 HRS in ascitic cirrhotic patients, following improvement in systemic hemodynamics with a combination of midodrine, octreotide, and albumin (medical treatment).

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