Susan M. McKiernan, Richard Hagan, Michael Curry, George S. A. McDonald, Alan Kelly, Niamh Nolan, Anne Walsh, John Hegarty, Emer Lawlor, Dermot Kelleher – 30 June 2004 – The role of cytotoxic T lymphocyte responses, restricted by human leukocyte antigen (HLA) class I alleles, is recognized as highly significant in the successful clearance of hepatitis C virus (HCV). The frequency of class I alleles in females inoculated with HCV genotype 1b from a single source was examined for an association with outcome.

Heping Yang, Mamatha R. Sadda, Mei Li, Ying Zeng, Lixin Chen, Wanjun Bae, Xiaopeng Ou, Maria T. Runnegar, José M. Mato, Shelly C. Lu – 30 June 2004 – S‐adenosylmethionine (SAMe) and its metabolite 5′‐methylthioadenosine (MTA) are proapoptotic in HepG2 cells. In microarray studies, we found SAMe treatment induced Bcl‐x expression. Bcl‐x is alternatively spliced to produce two distinct mRNAs and proteins, Bcl‐xL and Bcl‐xS. Bcl‐xL is antiapoptotic, while Bcl‐xS is proapoptotic.

Darius Moradpour – 30 June 2004

30 June 2004

Doris B. Strader, Teresa L. Wright, David L. Thomas, Leonard B. Seeff – 30 June 2004

30 June 2004

Rosendo Jardi, Francisco Rodriguez‐Frias, Maria Buti, Melanie Schaper, Auristela Valdes, Mariano Martinez, Rafael Esteban, Jaime Guardia – 30 June 2004 – The purpose of this study was to assess the use of dried blood spot (DBS) samples for hepatitis B virus (HBV) DNA quantification, HBV genotyping, and detection of G1896A precore mutants and variants in the YMDD polymerase motif.

Jian Wu, Li Liu, Roy D. Yen, Andreea Catana, Michael H. Nantz, Mark A. Zern – 30 June 2004 – Our previous study demonstrated that polycationic liposomes are highly stable in the bloodstream and represent an effective agent for liver gene delivery. We report here that liposome‐mediated extracellular superoxide dismutase (EC‐SOD) gene delivery successfully prevented acute liver injury in mice.

David A. Hendricks – 30 June 2004

Motoyuki Otsuka, Naoya Kato, Run‐Xuan Shao, Yujin Hoshida, Hideaki Ijichi, Yukihiro Koike, Hiroyoshi Taniguchi, Masaru Moriyama, Yasushi Shiratori, Takao Kawabe, Masao Omata – 30 June 2004 – Heatocellular carcinoma (HCC) is a common human malignancy. Its high mortality rate is mainly a result of high intrahepatic recurrence and portal venous invasion (PVI). We previously reported that the development of PVI is related to levels of des‐gamma‐carboxy prothrombin (DCP), a serum protein that increases at a notably higher rate in patients with HCC.