Fulminant hepatic failure: Outcome after listing for highly urgent liver transplantation—12 years experience in the nordic countries

Bjørn Brandsæter, Krister Höckerstedt, Styrbjörn Friman, Bo‐Göran Ericzon, Preben Kirkegaard, Helena Isoniemi, Michael Olausson, Ulrika Broome, Lars Schmidt, Aksel Foss, Kristian Bjøro – 30 December 2003 – Fulminant hepatic failure is a common indication for liver transplantation. Outcomes of patients listed for a highly urgent liver transplantation have been studied, with special emphasis on etiology of the liver disease, clinical condition, and ABO blood type. Data have been collected from the Nordic Liver Transplantation Registry.

Transplantation for hepatocellular carcinoma and cirrhosis: Sensitivity of magnetic resonance imaging

Glenn A. Krinsky, Vivian S. Lee, Neil D. Theise, Jeffrey C. Weinreb, Glyn R. Morgan, Thomas Diflo, Devon John, Lewis W. Teperman – 30 December 2003 – The sensitivity of magnetic resonance imaging (MRI) in patients who undergo transplantation for hepatocellular carcinoma (HCC) and cirrhosis is not known. We prospectively evaluated 24 patients with known HCC who underwent MRI and subsequent transplantation within 60 days (mean, 20 days). Using a phased‐array coil at 1.5T, breath‐hold turbo STIR and T2‐weighted MR images were performed.

Hepatitis B: Progress in the last 15 years

Federico G. Villamil – 30 December 2003 – 1Patients undergoing orthotopic liver transplantation (OLT) for hepatitis B without effective prophylaxis have a high risk for recurrent infection and severe graft damage, leading to death or re‐OLT.2Long‐term prophylaxis with hepatitis B immune globulin (HBIg) significantly reduces the risk for hepatitis B virus (HBV) recurrence and increases survival.

Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma: A safe and effective bridge to liver transplantation

Robert J. Fontana, Halimi Hamidullah, Hanh Nghiem, Joel K. Greenson, Hero Hussain, Jorge Marrero, Steve Rudich, Leslie A. McClure, Juan Arenas – 30 December 2003 – The incidence of hepatocellular carcinoma (HCC) is increasing in the United States. Although liver transplantation is an effective means of treating selected patients, pretransplantation tumor progression may preclude some patients from undergoing transplantation.

Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injury

Rahul S. Koti, Wenxuan Yang, Michael R. Dashwood, Brian R. Davidson, Alexander M. Seifalian – 30 December 2003 – Ischemic preconditioning (IPC) may protect the liver from ischemia reperfusion injury by nitric oxide formation. This study has investigated the effect of ischemic preconditioning on hepatic microcirculation (HM), and the relationship between nitric oxide metabolism and HM in preconditioning. Rats were allocated to 5 groups: 1. sham laparotomy; 2. 45 minutes lobar ischemia followed by 2‐hour reperfusion (IR); 3.

Conversion from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine is safe and cost‐effective in patients receiving long‐term prophylaxis to prevent hepatitis B recurrence after liver transplantation

Steven‐Huy Han, Paul Martin, Marc Edelstein, Rena Hu, Gregg Kunder, Curtis Holt, Sammy Saab, Francisco Durazo, Leonard Goldstein, Douglas Farmer, Rafik M. Ghobrial, Ronald W. Busuttil – 30 December 2003 – Recurrent hepatitis B infection after liver transplantation was previously frequent and associated with significant allograft failure and mortality. Recurrence rates of hepatitis B were improved with the use of passive immunoprophylaxis with hepatitis B immune globulin, and later, lamivudine monotherapy.

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