Sandrine Boyault, Aurélie Hérault, Charles Balabaud, Jessica Zucman‐Rossi – 22 February 2005

Alan Lee Rothman, Chihiro Morishima, Herbert L. Bonkovsky, Stephen J. Polyak, Ranjit Ray, Adrian M. Di Bisceglie, Karen L. Lindsay, Peter F. Malet, Ming Chang, David R. Gretch, Daniel G. Sullivan, Atul K. Bhan, Elizabeth C. Wright, Margaret James Koziel – 22 February 2005 – The relationships among host immune and viral factors and the severity of liver disease due to hepatitis C virus (HCV) are poorly understood. Previous studies have focused on individual components of the immune response to HCV, often in relatively small numbers of patients.

Masatoshi Kudo – 22 February 2005

Turgay Çelik, M. Zafer Gören, Kubilay Çınar, Hakan Gürdal, F. Oğuz Önder, Akif Tan, Berna Terzioğlu, A. Mithat Bozdayı, Hakan Bozkaya, Özden Uzunalimoğlu, Cihan Yurdaydin – 22 February 2005 – Fatigue associated with cholestasis may impair health‐related quality of life. The pathogenesis of this symptom is largely unknown, but it has been suggested that central serotoninergic neurotransmission may be implicated and that serotonin 1A receptor agonists may yield improvement.

Antony F. McDonagh – 22 February 2005

Simrat P. S. Saini, Ying Mu, Haibiao Gong, David Toma, Hirdesh Uppal, Songrong Ren, Song Li, Samuel M. Poloyac, Wen Xie – 22 February 2005 – The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin. Previous studies have suggested both overlapping and preferential regulation of target genes by these receptors, but the mechanism of cross‐talk remains elusive.

Massimo Primignani, Ida Martinelli, Paolo Bucciarelli, Tullia Battaglioli, Raffaella Reati, Federica Fabris, Alessandra Dell'Era, Emanuela Pappalardo, Pier Mannuccio Mannucci – 22 February 2005 – Scant information exists on the role of thrombophilia in extrahepatic portal vein obstruction (EHPVO).

Sabine Mihm – 22 February 2005

E. Ellen Schwegler, Lisa Cazares, Laura F. Steel, Bao‐Ling Adam, David A. Johnson, O. John Semmes, Timothy M. Block, Jorge A. Marrero, Richard R. Drake – 22 February 2005 – Proteomic profiling of serum is an emerging technique to identify new biomarkers indicative of disease severity and progression. The objective of our study was to assess the use of surface‐enhanced laser desorption/ionization time‐of‐flight mass spectrometry (SELDI‐TOF MS) to identify multiple serum protein biomarkers for detection of liver disease progression to hepatocellular carcinoma (HCC).

Russell H. Wiesner – 17 February 2005