Lamivudine after hepatitis B immune globulin is effective in preventing hepatitis B recurrence after liver transplantation

S. Forrest Dodson, Michael E. de Vera, C. Andrew Bonham, David A. Geller, Jorge Rakela, John J. Fung – 30 December 2003 – The prevention of recurrent hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) with hepatitis B immunoglobulin (HBIG) is expensive and requires indefinite parenteral administration. Lamivudine is a nucleoside analogue capable of inhibiting HBV replication.

Liver transplantation in Eastern Europe

Julius Špicák, Štefan Vítko, Miroslav Ryska, Pavel Trunecka, František Belina, Marek Krawczyk, Ferenc Perner, Pavel Taimr, Jan Šperl, Halima Hrncárková, Jan Peregrín, Helena Filipová, Karel Filip – 30 December 2003 – The aim of this report is to evaluate the development of liver transplantation in eastern Europe until mid‐1998. Representatives of gastroenterological and hepatological societies of the respective countries answered a questionnaire about the most descriptive items of the issue of liver transplantation.

Right hepatic lobectomy as a liver graft–saving procedure

Pierre Honoré, Olivier Detry, Etienne Hamoir, Thierry Defechereux, Bernard Detroz, Michel Meurisse, Nicolas Jacquet – 30 December 2003 – Retransplantation is common after liver transplantation (LT). However, in the present era of organ shortages, every attempt to save the liver graft should be performed before considering retransplantation. We report our experience with right hepatic lobectomy (RHL) for liver graft salvage. In a retrospective series of 180 adult LTs, 4 patients underwent RHL (Couinaud's segments V, VI, VII, VIII) in the post‐LT period.

Employment and alcohol use after liver transplantation for alcoholic and nonalcoholic liver disease: A systematic review

Dena M. Bravata, Ingram Olkin, Amber E. Barnato, Emmet B. Keeffe, Douglas K. Owens – 30 December 2003 – The purpose of the study is to evaluate patterns of employment and alcohol use among liver transplant recipients with alcoholic (ALD) and nonalcoholic liver disease (non‐ALD). MEDLINE, EMBASE, and bibliographic searches identified 5,505 potentially relevant articles published between January 1966 and October 1998. Eighty‐two studies reporting data on 5,020 transplant recipients met our inclusion criteria.

Double‐dose accelerated hepatitis B vaccine in patients with end‐stage liver disease

Mehmet Arslan, Russell H. Wiesner, Corey Sievers, Kathleen Egan, Nizar N. Zein – 30 December 2003 – The aims of this study are to assess the efficacy of hepatitis B virus (HBV) vaccination using an accelerated schedule and double dose of recombinant vaccine in liver transplant recipients and identify factors associated with seroconversion and persistence of antibody to hepatitis B surface antigen (anti‐HBs). Three hundred fifty‐six patients were enrolled.

Ischemic preconditioning of rat livers against cold storage‐reperfusion injury: Role of nonparenchymal cells and the phenomenon of heterologous preconditioning

Masahiro Arai, Ronald G. Thurman, John J. Lemasters – 30 December 2003 – Brief periods of ischemia followed by reperfusion render tissues resistant against subsequent prolonged ischemia, a phenomenon called ischemic preconditioning. The effect of ischemic preconditioning on liver transplantation was investigated in relation to sinusoidal endothelial cell injury and Kupffer‐cell activation, which are prominent features of storage and reperfusion injury leading to liver graft failure.

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