Noninvasive ventilation for pediatric patients including those under 1‐year‐old undergoing liver transplantation

Kazuo Chin, Shinji Uemoto, Ken‐ichi Takahashi, Hiroto Egawa, Mureo Kasahara, Yasuhiro Fujimoto, Kensuke Sumi, Michiaki Mishima, Colin E. Sullivan, Kouichi Tanaka – 21 January 2005 – Pulmonary complications are an important cause of the mortality associated with liver transplantation. The efficacy of noninvasive ventilation (NIV) in pediatric patients following transplantation is unknown. The purpose of this retrospective study is to investigate the effects of NIV for pediatric patients undergoing liver transplantation.

Liver transplantation with simultaneous removal of an intracardiac transjugular intrahepatic portosystemic shunt and a vena cava filter without the utilization of cardiopulmonary bypass

Paolo R.O. Salvalaggio, Alan J. Koffron, Jonathan P. Fryer, Michael M. Abecassis – 21 January 2005 – Transjugular intrahepatic shunts (TIPSs) are widely used in the management of portal hypertension complications including variceal bleeding, refractory ascites, and hepatic hydrothorax. Vena cava filters (VCFs) are an important therapeutic modality in the prevention of pulmonary emboli in patients suffering deep venous thrombosis and clinical contraindications for anticoagulation. Stent and filter misplacement or migration may occur, complicating liver transplantation (LT) surgery.

Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

Eduardo Schiffer, Chantal Housset, Wulfran Cacheux, Dominique Wendum, Christèle Desbois‐Mouthon, Colette Rey, François Clergue, Raoul Poupon, Véronique Barbu, Olivier Rosmorduc – 19 January 2005 – Epidermal growth factor receptor (EGFR) binds transforming growth factor α (TGF‐α) which is mitogenic for hepatocytes. Diverse lines of evidence suggest that activation of the TGF‐α /EGFR pathway contributes to hepatocellular carcinoma (HCC) formation.

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver

Blair U. Bradford, Hiroshi Kono, Fuyumi Isayama, Oksana Kosyk, Michael D. Wheeler, Taro E. Akiyama, Lisa Bleye, Kristopher W. Krausz, Frank J. Gonzalez, Dennis R. Koop, Ivan Rusyn – 19 January 2005 – The occurrence of malignant tumors of the upper gastrointestinal tract and liver is, based largely on epidemiological evidence, causally related to the consumption of ethanol. It is widely recognized that oxidants play a key role in alcohol‐induced liver injury; however, it is unclear how oxidants may be involved in DNA damage.

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