Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease

Joost P. H. Drenth, Esa Tahvanainen, Rene H. M. te Morsche, Pia Tahvanainen, Helena Kääriäinen, Krister Höckerstedt, Jiddeke M. van de Kamp, Martijn H. Breuning, Jan B. M. J. Jansen – 25 March 2004 – Mutations in protein kinase C substrate 80K‐H (PRKCSH), encoding for the protein hepatocystin, cause autosomal dominant polycystic liver disease (PCLD), which is clinically characterized by the presence of multiple liver cysts. PCLD has been documented in families from Europe (Netherlands, Belgium, Finland) as well as from the United States.

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP‐glucuronosyltransferase UGT1A4

Ursula Ehmer, Arndt Vogel, Jan Karl Schütte, Britta Krone, Michael P. Manns, Christian P. Strassburg – 25 March 2004 – UDP‐glucuronosyltransferases are a family of drug metabolizing enzymes contributing to hepatic drug metabolism and protection against environmental toxins. The aim of this study was to identify polymorphisms at the human UGT1A gene locus and to characterize their function and potential association with hepatocellular carcinoma (HCC).

Sinusoidal endothelial cell and hepatocyte death following cold ischemia‐warm reperfusion of the rat liver

Pierre‐Michel Huet, Marcia R. Nagaoka, Geneviève Desbiens, Esther Tarrab, Antoine Brault, Marie‐Pierre Bralet, Marc Bilodeau – 25 March 2004 – Cold ischemia‐warm reperfusion (CI‐WR) injury of the liver is characterized by marked alterations of sinusoidal endothelial cells (SECs), whereas hepatocytes appear to be relatively unscathed. However, the time course and mechanism of cell death remain controversial: early versus late phenomenon, necrosis versus apoptosis?

Electric foot shock stress‐induced exacerbation of α‐galactosylceramide–triggered apoptosis in mouse liver

Yoichi Chida, Nobuyuki Sudo, Junko Sonoda, Hiroshi Sogawa, Chiharu Kubo – 25 March 2004 – Recently, liver natural killer T (NKT) cells, which are specifically stimulated by α‐galactosylceramide (α‐GalCer), were found to play a critical role in intrahepatic immunity to several infections and certain hepatic disorders. However, the role of psychophysical stress on NKT cell–dependent liver injury induced by α‐GalCer still remains to be elucidated.

Integration of woodchuck hepatitis and N‐myc rearrangement determine size and histologic grade of hepatic tumors

James R. Jacob, Agnes Sterczer, Ilia A. Toshkov, Amy E. Yeager, Brent E. Korba, Paul J. Cote, Marie‐Annick Buendia, John L. Gerin, Bud C. Tennant – 25 March 2004 – Integrations of woodchuck hepatitis virus (WHV) DNA and rearrangements of the N‐myc 2 gene have been detected frequently in hepatocellular carcinoma (HCC) of Eastern woodchucks (Marmota monax) chronically infected with WHV.

HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination

Chengbin Wang, Jianming Tang, Wei Song, Elena Lobashevsky, Craig M. Wilson, Richard A. Kaslow – 25 March 2004 – Variable immune responses to hepatitis B virus (HBV) infection and recombinant HBV vaccines have been associated with polymorphisms in several genes within the human leukocyte antigen (HLA) complex.

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