A concise update on the status of liver transplantation for hepatitis B virus: The challenges in 2002

Hugo E. Vargas, Forrest S. Dodson, Jorge Rakela – 30 December 2003 – Significant improvements in both patient and graft survival after orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)‐related liver failure have been made during the last decade. Recurrence of HBV infection has decreased, even in high‐risk patients.

Temporal profile of total, bound, and free Gc‐globulin after acetaminophen overdose

Frank Vinholt Schiødt, Peter Ott, Niels Tygstrup, Benny Dahl, Stig Bondesen – 30 December 2003 – Low admission values of the actin scavenger Gc‐globulin are associated with an adverse outcome in acetaminophen (paracetamol) overdose. This prospective longitudinal study including 84 patients with acetaminophen overdose characterizes the temporal profile of Gc‐globulin during the entire length of hospitalization. Serum Gc‐globulin (total, actin bound, and free) levels and actin‐complex ratio were measured on admission and every 12 hours until discharge.

Immune response to influenza vaccine in adult liver transplant recipients

Andrea Duchini, R. Michael Hendry, Lisa M. Nyberg, M. Eric Viernes, Paul J. Pockros – 30 December 2003 – Influenza virus infection may cause significant complications in liver transplant recipients, and whether vaccination is effective in these patients is controversial. We performed a study to assess the immune response to influenza vaccine in liver transplant recipients and patients with cirrhosis compared with healthy controls.

Use of intraoperative Doppler ultrasound to diagnose hepatic venous obstruction in a right lobe living donor liver transplant

Robert S. Shapiro, Thomas Fishbein, Myron Schwartz, Charles M. Miller – 30 December 2003 – Right lobe liver transplantation is a relatively new and technically challenging method of living donor transplantation. Integrity of the hepatic venous anastomosis is crucial for successful transplantation. We describe the use of intraoperative Doppler sonography to diagnose stenosis of the hepatic vein anastomosis, with associated compromise of venous drainage and graft perfusion.

Hepatic artery thrombosis after orthotopic liver transplantation: A review of nonsurgical causes

Sabrina Pastacaldi, Rosangela Teixeira, Paolo Montalto, Keith Rolles, Andrew K. Burroughs – 30 December 2003 – Hepatic artery thrombosis (HAT) is one of the principal causes of morbidity and graft loss following liver transplantation. There are several risk factors for the development of HAT; technical aspects of the arterial anastomosis are important particularly for early thrombosis, but the improvement of surgical technique has lessened this problem.

Recurrent autoimmune hepatitis after orthotopic liver transplantation

Alvaro González‐Koch, Albert J. Czaja, Herschel A. Carpenter, Stuart K. Roberts, Michael R. Charlton, Michael K. Porayko, Charles B. Rosen, Russell H. Wiesner – 30 December 2003 – To determine the frequency, risk factors, and consequences of recurrent autoimmune hepatitis after liver transplantation, 41 patients with type 1 disease were monitored after surgery in accordance with a surveillance protocol. Tacrolimus or cyclosporine plus prednisone were administered to each patient, and liver biopsy examinations were performed at least annually according to protocol.

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