Hepatic overexpression of caveolins increases bile salt secretion in mice

Mauricio Moreno, Hector Molina, Ludwig Amigo, Silvana Zanlungo, Marco Arrese, Attilio Rigotti, Juan Francisco Miquel – 30 December 2003 – Caveolins are cholesterol‐binding proteins involved in the regulation of several intracellular processes, including cholesterol transport. Because hepatocytes express caveolin‐1 and caveolin‐2, these proteins might modulate hepatic lipid metabolism and biliary lipid secretion. Our aim was to investigate the potential physiologic role of caveolins in hepatic cholesterol and bile salt (BS) metabolism and transport using adenoviral gene transfer.

Results of retransplantation for recurrent hepatitis C

Sasan Roayaie, Thomas D. Schiano, Swan N. Thung, Sukru H. Emre, Thomas M. Fishbein, Charles M. Miller, Myron E. Schwartz – 30 December 2003 – Retransplantation for recurrent hepatitis C virus (HCV) has been evaluated in small series. In this study, patients undergoing transplantation for HCV‐related cirrhosis with subsequent retransplantation more than 90 days for recurrent HCV (proven by pathologic examination of the explant and exclusion of other factors) were prospectively followed.

Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver

Orlando Musso, Marko Rehn, Janna Saarela, Nathalie Théret, Jocelyne Liétard, Elina Hintikka, Dominique Lotrian, Jean‐Pierre Campion, Taina Pihlajaniemi, Bruno Clément – 30 December 2003 – Type XVIII collagen is a recently discovered nonfibrillar collagen associated with basement membranes in mice and expressed at high levels in human liver.

Subclinical hepatic encephalopathy impairs daily functioning

Michael Groeneweg, Juan C. Quero, Ilone De Bruijn, Ieneke J.C. Hartmann, Marie‐louise Essink‐bot, Wim C.J Hop, Solko W. Schalm – 30 December 2003 – Subclinical hepatic encephalopathy (SHE) is assumed to have a negative effect on patients' daily functioning; therefore, treatment is recommended. However, no studies have been performed that document the clinical relevance of SHE.

Changes in lymph vessels and portal veins in the portal tract of patients with idiopathic portal hypertension: A morphometric study

Hiroki Oikawa, Tomoyuki Masuda, Shin‐Ichiro Sato, Akiko Yashima, Kazuyuki Suzuki, Shunichi Sato, Ryoichi Satodate – 30 December 2003 – Little is known about the effects of the pathological process associated with idiopathic portal hypertension (IPH) on hepatic lymph vessels or lymph flow. We used morphometric analysis to examine IPH‐associated changes in lymph vessels and branches of the portal vein, with use of immunohistochemical staining for alpha smooth muscle actin. We also quantitated these changes using an image analysis system.

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