Ted A. Gooley, Pankaj Rajvanshi, H. Gary Schoch, George B. McDonald – 19 January 2005 – Many patients who undergo hematopoietic cell transplantation experience liver injury. We examined the association of serum bilirubin levels with nonrelapse mortality by day +200, testing the hypothesis that the duration of jaundice up to a given point in time provides more prognostic information than either the maximum bilirubin value or the value at that point in time. We studied 1,419 consecutive patients transplanted from allogeneic donors.

Osman Cavit Ozdogan – 19 January 2005

Barbara Akhurst, Vance Matthews, Kirsten Husk, Mark J. Smyth, Lawrence J. Abraham, George C. Yeoh – 19 January 2005 – The liver regenerates after acute injury via hepatocyte cell division; during chronic injury, when hepatocyte replication is impaired or blocked, liver progenitor oval cells mediate liver regeneration. If both regeneration options are blocked in animal models, then liver failure and death ensues. The mechanisms underlying oval cell induction, proliferation, and subsequent liver regeneration remain poorly characterized.

Lars Zender, Sebastian Hütker, Bettina Mundt, Morlen Waltemathe, Christian Klein, Christian Trautwein, Nisar P. Malek, Michael Peter Manns, Florian Kühnel, Stefan Kubicka – 19 January 2005 – Inhibition of NFκB enhances the susceptibility of cancer to TRAIL‐mediated apoptosis and is suggested as a strategy for cancer therapy. Because the role of NFκB in TRAIL‐mediated apoptosis of hepatocytes is unknown, we investigated the influence of NFκB‐inhibition in death ligand‐mediated apoptosis in hepatitis.

Thomas D. Boyer, Ziv J. Haskal – 19 January 2005

Thomas F. Baumert, Chun Yang, Peter Schürmann, Josef Köck, Christian Ziegler, Carsten Grüllich, Michael Nassal, T. Jake Liang, Hubert E. Blum, Fritz von Weizsäcker – 19 January 2005 – Hepatitis B virus (HBV) core promoter mutations have been implicated in the pathogenesis of fulminant hepatitis B. Due to the limited availability of primary human hepatocytes, the functional characterization of HBV mutants has been performed predominantly in transformed cells, which may not represent ideal model systems for studying virus–cell interactions.

Hirdesh Uppal, David Toma, Simrat P.S. Saini, Songrong Ren, Thomas J. Jones, Wen Xie – 23 December 2004 – Efficient detoxification of bile acids is necessary to avoid pathological conditions such as cholestatic liver damage and colon cancer. The orphan nuclear receptors PXR and CAR have been proposed to play an important role in the detoxification of xeno‐ and endo‐biotics by regulating the expression of detoxifying enzymes and transporters.

Jason A. Dominitz, Edward J. Boyko, Thomas D. Koepsell, Patrick J. Heagerty, Charles Maynard, Jennifer L. Sporleder – 23 December 2004 – Several studies suggest veterans have a higher prevalence of hepatitis C virus infection than nonveterans, possibly because of military exposures. The purpose of this study was to estimate the prevalence of anti–hepatitis C antibody and evaluate factors associated with infection among users of Department of Veterans Affairs medical centers.

Jia‐Horng Kao, Ding‐Shinn Chen – 23 December 2004

Takashi Kamihira, Shinji Shimoda, Minoru Nakamura, Teruhumi Yokoyama, Yasushi Takii, Akira Kawano, Mizuki Handa, Hiromi Ishibashi, M.