Hepatitis C virus‐infected patients report communication problems with physicians

Susan Zickmund, Stephen L. Hillis, Mitchell J. Barnett, Laura Ippolito, Douglas R. LaBrecque – 25 March 2004 – We examined the prevalence and nature of perceived problems in the interaction between physicians and patients diagnosed with hepatitis C virus (HCV) infection. This cross‐sectional study included 322 outpatients diagnosed with chronic HCV infection and treated at a tertiary referral hospital's hepatology clinic.

Kupffer cells required for high affinity peptide‐induced deletion, not retention, of activated CD8+ T cells by mouse liver

Yuhshi Kuniyasu, Suhail Mohammed Marfani, Irteza Bin Inayat, Shehzad Zafar Sheikh, Wajahat Zafar Mehal – 25 March 2004 – The immune response to foreign antigens in the liver is often suboptimal and this is clinically relevant in chronic persistence of hepatotropic viruses. In chronic infection with the hepatitis C virus, activated CD8+ T cells specific for viral epitopes are present in the peripheral blood and the liver, yet viral clearance is unusual.

Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post–cold ischemic rat liver

Atsushi Kudo, Satoshi Kashiwagi, Mayumi Kajimura, Yasunori Yoshimura, Koji Uchida, Shigeki Arii, Makoto Suematsu – 25 March 2004 – Although Kupffer cells (KCs) may play a crucial role in post–cold ischemic hepatocellular injury, their role in nonnecrotic graft dysfunction remains unknown. This study examined reveal the role of KC in post–cold ischemic liver grafts.

Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia

Dong‐Yi Zhang, Gregg Sabla, Pranavkumar Shivakumar, Greg Tiao, Ronald J. Sokol, Cara Mack, Benjamin L. Shneider, Bruce Aronow, Jorge A. Bezerra – 25 March 2004 – The molecular basis for the embryonic and perinatal clinical forms of biliary atresia is largely undefined. In this study, we aimed to: 1) determine if the clinical forms can be differentiated at the transcriptional level, and 2) search for molecular mechanisms underlying phenotypic differences.

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors

Natalia L. Lazarevich, Oksana A. Cheremnova, Ekaterina V. Varga, Dmitry A. Ovchinnikov, Elena I. Kudrjavtseva, Olga V. Morozova, Daria I. Fleishman, Natalia V. Engelhardt, Stephen A. Duncan – 25 March 2004 – Hepatocyte nuclear factors (HNF) play a critical role in development of the liver. Their roles during liver tumorigenesis and progression of hepatocellular carcinomas (HCC) are, however, poorly understood.

Treatment of chronic hepatitis C in HIV/HCV‐coinfection with interferon α‐2b+ full‐course vs. 16‐week delayed ribavirin

Norbert Bräu, Maribel Rodriguez‐Torres, Dale Prokupek, Maurizio Bonacini, Carol A. Giffen, Jeffery J. Smith, Kevin R. Frost, Jay R. Kostman – 25 March 2004 – Human immunodeficiency virus (HIV)‐infected patients increasingly experience the consequences of chronic hepatitis C virus (HCV) coinfection. This trial randomized 107 patients coinfected with HIV and HCV to receive 48 weeks of interferon alfa‐2b (IFN) 3 million units three times weekly plus either a full course of ribavirin (RBV) at 800 mg/day (group A; n = 53) or 16 weeks of placebo, followed by RBV (group B; n = 54).

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