Model for end‐stage liver disease and Child‐Turcotte‐Pugh score as predictors of pretransplantation disease severity, posttransplantation outcome, and resource utilization in United Network for Organ Sharing status 2A patients

Robert S. Brown, K. Shiva Kumar, Mark W. Russo, Milan Kinkhabwala, Dianne L. Rudow, Patricia Harren, Steven Lobritto, Jean C. Emond – 30 December 2003 – The Model for End‐Stage Liver Disease (MELD) has been proposed as a replacement for the Child‐Turcotte‐Pugh (CTP) classification to stratify patients for prioritization for orthotopic liver transplantation (OLT).

Current practice regarding the use of fatty livers: A Trans‐Atlantic survey

Charles J. Imber, Shawn D. St. Peter, Inigo Lopez, Lynden Guiver, Peter J. Friend – 30 December 2003 – A strong association exists between the presence of steatosis in a donor liver for transplantation and the development of primary nonfunction in the recipient. Despite this, appraisal of the donor remains one of the least scientific aspects of the transplantation process, and many centers base their practice on subjective opinion, rather than objective data.

Hepatic steatosis and its relationship to transplantation

Charles J. Imber, Shawn D. St. Peter, Ashok Handa, Peter J. Friend – 30 December 2003 – Fatty infiltration of the liver is common in the brain‐dead donor population and has a strong correlation with primary nonfunction after cold preservation, a condition that is catastrophic to liver transplant recipients. This literature review examines factors associated with the development, diagnosis, quantification, and clinical management of this difficult condition.

Pulmonary gas exchange abnormalities in liver transplant candidates

Rosmawati Mohamed, Jonathan W. Freeman, Peter J. Guest, Michael K. Davies, James M. Neuberger – 30 December 2003 – Abnormal diffusing capacity is the commonest pulmonary dysfunction in liver transplant candidates, but severe hypoxemia secondary to hepatopulmonary syndrome and significant pulmonary hypertension are pulmonary vascular manifestations of cirrhosis that may affect the perioperative course. We prospectively assessed the extent of pulmonary dysfunction in patients referred for liver transplantation. A total of 57 consecutive patients with chronic liver disease were evaluated.

Reduced use of intensive care after liver transplantation: Patient attributes that determine early transfer to surgical wards

M. Susan Mandell, Dennis Lezotte, Igal Kam, Stacy Zamudio – 30 December 2003 – Part 1 of our report, presented in the same issue of the Journal, shows that immediate postoperative extubation and direct transfer to the surgical ward is safe and reduces reliance on the intensive care unit in most liver transplant recipients. However, there is no method to preoperatively predict which patients will need ventilatory support after surgery.

Liver transplantation in association with hepatocellular carcinoma: An update of the international tumor registry

Ernesto P. Molmenti, Goran B. Klintmalm – 30 December 2003 – Hepatocellular carcinoma is an epithelial tumor derived from hepatocytes that accounts for more than 80% of all primary hepatic tumors. The severity of the underlying disease is almost always the key factor in deciding whether to consider liver resection or transplantation as its treatment.

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