Glutathione, lactobionate, and histidine: cryptic inhibitors of matrix metalloproteinases contained in university of wisconsin and histidine/tryptophan/ketoglutarate liver preservation solutions

Gundumi Aravinda Upadhya, Steven M. Strasberg – 30 December 2003 – UW solution and HTK solution are both used for cold preservation of liver allografts. Although they are about equally effective, their compositions are very different, and they were formulated using different rationales. The authors recently showed an important role for MMPs in liver preservation injury and consequently postulated that these preservation solutions contain cryptic inhibitors of MMP activity. To determine this possibility, the ability of these solutions to inhibit MMP activity was studied.

Molecular mechanisms of tumor necrosis factor α–stimulated leukocyte recruitment into the murine hepatic circulation

Alison Fox‐Robichaud, Paul Kubes – 30 December 2003 – To date, much of the adhesion work in the liver has been restricted to sinusoids and postsinusoidal venules. However, selectins have been localized on the portal (presinusoidal) venules and these vessels have been shown to be important in metastasis of tumors. The purpose of this study was to characterize the leukocyte‐endothelial interactions within the 3 compartments of the hepatic microvasculature under baseline conditions and in response to tumor necrosis factor α (TNF‐α).

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