Professor Kunio Okuda
Paul D. Berk – 30 December 2003
A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector
Carlo Giannini, Serban Morosan, J. Guilherme Tralhao, Jacques Emmanuel Guidotti, Serena Battaglia, Karine Mollier, Laurent Hannoun, Dina Kremsdorf, Helene Gilgenkrantz, Pierre Charneau – 30 December 2003 – Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplantation.
PPARγ ligands inhibit cholangiocarcinoma cell growth through p53‐dependent GADD45 and p21WAF1/Cip1 pathway
Chang Han, A. Jake Demetris, George K. Michalopoulos, Qimin Zhan, James H. Shelhamer, Tong Wu – 30 December 2003 – Ligands of peroxisome proliferator‐activated receptor‐γ (PPARγ) induce differentiation and growth inhibition in several human cancers. However, the role of PPARγ ligands in the growth control of human cholangiocarcinoma cells remains unknown. This study was designed to investigate the biological functions and molecular mechanisms of PPARγ ligands in the growth regulation of human cholangiocarcinoma cells.
Interferon therapy in hepatitis B e antigen–negative chronic hepatitis B
Agostino Colli, Sara Massironi, Marco Anreoletti – 30 December 2003
Heme oxygenase in liver transplantation: Heme catabolism and metabolites in the search of function
Michael Bauer – 30 December 2003
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
Kyung‐Ran You, Ming‐Jie Liu, Xue‐Ji Han, Zee‐Won Lee, Dae‐Ghon Kim – 30 December 2003 – The transcription factor CHOP/GADD153 is reportedly induced by cellular stresses such as UV light, genotoxic agents, and protein misfolding in the endoplasmic reticulum. However, the mechanism whereby induction of the GADD153 gene is linked to a downstream pathway is still unclear.
Epidemiology of primary hepatic malignancies in U.S. children
Anil Darbari, Keith M. Sabin, Craig N. Shapiro, Kathleen B. Schwarz – 30 December 2003 – The epidemiology of primary hepatic malignancies in U.S. children is poorly characterized. We analyzed the incidence, mortality, and characteristics of primary hepatic malignancies in U.S. residents less than 20 years of age. Fatal primary hepatic malignancies in persons less than 20 years of age, between 1979 and 1996, were identified using the multiple‐cause‐of‐death database (National Center for Health Statistics).
Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization
Nicholas A. Shackel, Peter H. McGuinness, Catherine A. Abbott, Mark D. Gorrell, Geoffrey W. McCaughan – 30 December 2003 – Pathogenic molecular pathways in cirrhotic liver diseases such as hepatitis C virus (HCV), autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly characterized. Differentially expressed genes are often important in disease pathogenesis. Suppression subtractive hybridization (SSH) is a genome‐wide approach that enriches for differentially expressed mRNA transcripts.
CC531S‐induced damage of the rat liver sinusoidal endothelial lining is mediated by the Fas/FasL pathway
Katrien Vekemans, Filip Braet, Eddie Wisse – 30 December 2003
Adenovirus‐mediated expression of Cu/Zn‐ or Mn‐superoxide dismutase protects against CYP2E1‐dependent toxicity
María José Pérez, Arthur I. Cederbaum – 30 December 2003 – CYP2E1 induction by ethanol is one mechanism by which ethanol creates oxidative stress in the liver. The superoxide dismutases (SODs) are an important antioxidant enzyme defense system against reactive oxygen species (ROS). To investigate the protective role of SOD against CYP2E1‐dependent toxicity, a transfected HepG2 cell line overexpressing CYP2E1 (E47 cells) was infected with adenoviral vectors containing Cu/Zn‐SOD complementary DNA (cDNA) (Ad.SOD1) and Mn‐SOD cDNA (Ad.SOD2).