Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase‐dependent pathway

Surinder S. Yadav, David Sindram, David K. Perry, Pierre‐Alain Clavien – 30 December 2003 – A short period of ischemia and reperfusion, called ischemic preconditioning, protects various tissues against subsequent sustained ischemic insults. We previously showed that apoptosis of hepatocytes and sinusoidal endothelial cells is a critical mechanism of injury in the ischemic liver.

The transforming growth factor β1–inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress

Afonso Ribeiro, Steven F. Bronk, Patricia J. Roberts, Raul Urrutia, Gregory J. Gores – 30 December 2003 – Transforming growth factor β1(TGF‐β1)–inducible transcription factors have recently elicited interest because of their critical role in the regulation of cell proliferation, differentiation, and apoptosis. We have previously reported that the TGF‐β1 –inducible transcription factor, TIEG1, induces apoptosis in a pancreas‐derived cell line. However, the mechanisms underlying the apoptotic effects of this transcription factor remain to be defined.

Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C virus–related cirrhosis

Àngels Escorsell, Concepció Bru, Rosa Gilabert, Eduardo Moitinho, Juan Carlos García‐Pagán, Jaume Bosch – 30 December 2003 – Wedged hepatic venous pressure (WHVP) is equivalent to portal venous pressure in patients with alcoholic liver diseases. However, it may underestimate portal pressure in nonalcoholics, which is important because hepatitis C virus (HCV) infection is a frequent cause of chronic liver disease. We investigated the agreement between directly measured portal pressure and WHVP in alcoholic and HCV–related liver diseases.

Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

Vinicio Carloni, Massimo Pinzani, Sabrina Giusti, Roberto G. Romanelli, Maurizio Parola, Giorgio Bellomo, Paola Failli, Andrew D. Hamilton, Said M. Sebti, Giacomo Laffi, Paolo Gentilini – 30 December 2003 – Focal adhesion kinase (FAK) is a widely expressed nonreceptor tyrosine kinase found in focal adhesions. FAK has been indicated as a point of convergence of other signaling pathways including platelet‐derived growth factor (PDGF) receptors, and recently, FAK tyrosine phosphorylation has been shown to be stimulated by PDGF.

Association of diabetes, serum insulin, and c‐peptide with gallbladder disease

Constance E. Ruhl, James E. Everhart – 30 December 2003 – An inconsistent association has been found between gallbladder disease and diabetes mellitus. We hypothesized that insulin resistance rather than diabetes status may be a primary factor involved in gallstone formation. A total of 5,653 adult participants in the third United States National Health and Nutrition Examination Survey without known diabetes underwent gallbladder ultrasonography and phlebotomy after an overnight fast for measurement of serum insulin, C‐peptide, and glucose.

Cost‐effectiveness of different strategies of cytomegalovirus prophylaxis in orthotopic liver transplant recipients

Ananya Das – 30 December 2003 – Cytomegalovirus (CMV) is an important cause of morbidity and mortality in liver transplant recipients and several different strategies of CMV chemoprophylaxis are in practice. A cost‐effective analysis was performed to compare these strategies. A hypothetical cohort of liver transplant recipients was followed up for a year posttransplantation in a Markov model, as they made possible transitions to different states of health with respect to CMV infection and disease. Different strategies of chemoprophylaxis were compared.

Subscribe to