Insulin inhibits secretin‐induced ductal secretion by activation of PKC alpha and inhibition of PKA activity

Gene D. LeSage, Luca Marucci, Domenico Alvaro, Shannon S. Glaser, Antonio Benedetti, Marco Marzioni, Tushar Patel, Heather Francis, Jo Lynne Phinizy, Gianfranco Alpini – 30 December 2003 – Insulin stimulates canalicular bile flow by interaction with hepatocytes. Insulin regulates the function of a number of epithelia through activation and membrane translocation of Ca2+‐dependent PKC isoforms. No information exists regarding insulin regulation of ductal bile secretion.

Prevention of bile acid–induced apoptosis by betaine in rat liver

Dirk Graf, Anna Kordelia Kurz, Roland Reinehr, Richard Fischer, Gerald Kircheis, Dieter Häussinger – 30 December 2003 – Bile acid–induced apoptosis plays an important role in the pathogenesis of cholestatic liver disease, and its prevention is of therapeutic interest. The effects of betaine were studied on taurolithocholate 3‐sulfate (TLCS) and glycochenodeoxycholate (GCDC)‐induced apoptosis in rat hepatocytes in vitro and in vivo.

Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S‐transferase P1 polymorphism

Alexandra Henrion‐Caude, Cyril Flamant, Michel Roussey, Chantal Housset, Antoine Flahault, Anthony A. Fryer, Katarina Chadelat, Richard C. Strange, Annick Clement – 30 December 2003 – Liver disease in patients with cystic fibrosis (CF) is inconstant and has not yet been clearly related to any specific risk factor.

Racial differences in effectiveness of α‐fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis

Mindie H. Nguyen, Ruel T. Garcia, Peter W. Simpson, Teresa L. Wright, Emmet B. Keeffe – 30 December 2003 – α‐Fetoprotein (AFP) is frequently used as a diagnostic marker for hepatocellular carcinoma (HCC). Most available data concerning AFP come from studies of patients with chronic hepatitis B or other chronic liver diseases of mixed etiologies. Limited data concerning the diagnostic value of AFP for hepatitis C virus (HCV)‐related HCC have to date come only from Asian and European studies, and results are conflicting.

Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells for parallel expansion during liver regeneration after partial hepatectomy in mice

Toshiki Sakamoto, Tsukasa Ezure, John Lunz, Noriko Murase, Hirokazu Tsuji, John J. Fung, Anthony J. Demetris – 30 December 2003 – Liver hematopoietic progenitor cells (LHPC) and liver epithelial progenitor cells (LEPC) share a remarkable number of growth and differentiation‐controlling receptor‐ligand signaling systems. These likely account for the ability of the liver to support hematopoiesis in fetal life, and possibly for suggestions that LHPC can differentiate into hepatocytes.

Cold‐preservation–induced sensitivity of rat hepatocyte function to rewarming injury and its prevention by short‐term reperfusion

Katarína Vajdová, Renáta Smreková, Csilla Mišlanová, Marián Kukan, Martina Lutterová – 30 December 2003 – With increasing time of cold preservation, levels of high‐energy nucleotides in the liver are reducing. The authors hypothesized that cold preservation sensitizes hepatocyte function to ischemic injury occurring during graft rewarming and that the injury can be prevented by short‐term reperfusion. Rat livers were cold‐preserved in University of Wisconsin solution for 0 to 18 hours and ischemically rewarmed for 0 to 45 minutes to simulate the implantation stage of transplantation.

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