Risk factors for recurrence of hepatitis C after liver transplantation

J. Ignacio Herrero, Andrés de Peña, Jorge Quiroga, Bruno Sangro, Nicolás Garcia, Iosu Sola, Javier A. Cienfuegos, Maria P. Civeira, Jesús Prieto – 30 December 2003 – Recurrent hepatitis C is a frequent complication after liver transplantation for hepatitis C virus–related cirrhosis, but risk factors related to its development remain ill defined. Twenty‐three patients receiving a primary liver graft for hepatitis C virus–related cirrhosis and with an assessable biopsy performed at least 6 months after liver transplantation were studied retrospectively.

Predictors of bile leaks after T‐tube removal in orthotopic liver transplant recipients

Margaret C. Shuhart, Kris V. Kowdley, John P. McVicar, Charles A. Rohrmann, Mary F. McDonald, Donald W. Wadland, Scott S. Emerson, Robert L. Carithers, Michael B. Kimmey – 30 December 2003 – Bile leaks after T‐tube removal are a frequent cause of morbidity in orthotopic liver transplant recipients. The aim of this study was to determine factors that predict the development of these leaks in liver transplant recipients. Records of all patients who had undergone liver transplantation at the University of Washington Medical Center between January 1990 and September 1993 were reviewed.

Gastric mucosal pH is associated with initial graft function but is not a predictor of major morbidity after liver transplantation

J K Maring, I J Klompmaker, J H Zwaveling, R Verwer, M J Slooff – 30 December 2003 – Gastric mucosal pH reflects splanchnic perfusion. Monitoring gastric mucosal pH might be useful in predicting outcome after liver transplantation. Forty patients were included in the study. Gastric mucosal pH and gastric mucosal pH corrected for systemic pH were compared with regard to initial liver function and morbidity. Eighty percent of the patients had at least one episode with a gastric mucosal pH of <7.32, and 84% of these had a concomitant arterial pH of <7.32.

Hepatitis C virus genotypes and quantitation of serum hepatitis C virus RNA in liver transplant recipients: Relationship with severity of histological recurrence and implications in the pathogenesis of HCV infection

G P Pageaux, J Ducos, A M Mondain, V Costes, M C Picot, P F Perrigault, J Domergue, D Larrey, H Michel – 30 December 2003 – The reasons for the wide variation of incidence and severity of recurrent hepatitis C after liver transplantation are not clear. We have studied liver transplant recipients to assess the impact of hepatitis C virus (HCV) genotype and HCV RNA quantification on HCV recurrence after transplantation. Twenty‐two patients received transplants for HCV cirrhosis and were followed up with virological and histological assessments. Mean follow‐up was 39 months.

Apoptosis after ischemia‐reperfusion in human liver allografts

G Borghi‐Scoazec, J Y Scoazec, F Durand, J Bernuau, J Belghiti, G Feldmann, D Henin, C Degott – 30 December 2003 – Little is known about the possible contribution of apoptosis to ischemia‐reperfusion injury in human liver transplantation. Therefore, we studied postreperfusion surgical biopsy specimens of 16 human liver allografts using the TUNEL assay for in situ demonstration of apoptotic cells. In all patients, a variable proportion of hepatocytes and sinusoidal endothelial cells presented labeled nuclei.

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