Liver transplantation outcomes for early‐stage hepatocellular carcinoma: Results of a multicenter study

Jessica Y. Leung, Andrew X. Zhu, Fredric D. Gordon, Daniel S. Pratt, Abigail Mithoefer, Kathryn Garrigan, Adam Terella, Martin Hertl, A. Benedict Cosimi, Raymond T. Chung – 20 October 2004 – The incidence of hepatocellular carcinoma (HCC), a frequent and incurable complication of cirrhosis, continues to rise. Orthotopic liver transplantation (OLT) has been proposed as a treatment for unresectable, intrahepatic HCC limited in extent to the Milan criteria adopted by the United Network of Organ Sharing (UNOS) in 1998.

Risk factors for renal dysfunction in the postoperative course of liver transplant

Miguel Lebrón Gallardo, Manuel E. Herrera Gutierrez, Gemma Seller Pérez, Emilio Curiel Balsera, Juan F. Fernández Ortega, Guillermo Quesada García – 20 October 2004 – Renal dysfunction (RD) is a frequent complication after orthotopic liver transplantation (OLT), and it has an unfavorable effect on the prognosis of OLT patients. The purpose of our study was to identify possible risk factors for RD and its impact on survival.

Survival of cirrhotic patients with early hepatocellular carcinoma treated by percutaneous ethanol injection or liver transplantation

Angelo Andriulli, Ilario de Sio, Luigi Solmi, Luciano De Carlis, Roberto Troisi, Alessandro Grasso, Virginia Festa, Eugenio Caturelli, Alessandro Giacomoni, Camillo Del Vecchio Blanco, Bernard De Hemptinne, Andrew Burroughs, Francesco Perri – 20 October 2004 – For “early” hepatocellular carcinoma (HCC), surgery, orthotopic liver transplantation (OLT) and percutaneous ethanol injection (PEI) improve the natural history of the disease. We performed a retrospective study to evaluate the outcome of patients with cirrhosis and early HCC treated by PEI (n = 417) or OLT (n = 172).

Detection of recipient's cells in liver graft using antibodies to mismatched HLA class I antigens

Alberto Grassi, Micaela Susca, Matteo Ravaioli, Gian Luca Grazi, Antonia D'Errico, Andrea Bontadini, Daniela Zauli, Antonio Pinna, Francesco B. Bianchi, Giorgio Ballardini – 20 October 2004 – Engraftment by recipient's (R) cells has been already demonstrated in gender mismatched liver grafts using fluorescence in situ hybridization (FISH), with contrasting results concerning epithelial cells. Mismatch for human leukocyte antigen (HLA) class I (HLA‐I) is quite common in patients with orthotopic liver transplantation (OLT).

Simplified standardized technique for living donor liver transplantation using left liver graft plus caudate lobe

Shin Hwang, Sung‐Gyu Lee, Tae‐Yong Ha, Chul‐Soo Ahn, Kwang‐Min Park, Ki‐Hun Kim, Young‐Joo Lee, Deok‐Bog Moon, Keon‐Kuk Kim, Yeon‐Dae Kim – 20 October 2004 – Concomitant resection of the caudate lobe (CL) would increase the liver mass in the left liver graft. We tried to define a simplified standardized technique for adult living donor liver transplantation using the extended left lobe (ELL) plus CL (ELLC) through a prospective study of 27 consecutive ELLC graft cases in 2003.

ACAT2 deficiency limits cholesterol absorption in the cholesterol‐fed mouse: Impact on hepatic cholesterol homeostasis

Joyce J. Repa, Kimberly K. Buhman, Robert V. Farese, John M. Dietschy, Stephen D. Turley – 14 October 2004 – Acyl CoA:cholesterol acyltransferase (ACAT) 2 is the major cholesterol‐esterifying enzyme in mouse enterocytes and hepatocytes. Male ACAT2+/+ and ACAT2−/ − mice were fed chow containing added cholesterol (0%‐0.500% w/w) for 24 days. Over this range, fractional cholesterol absorption in the ACAT2+/+ mice fell from 41.4% ± 6.6% to 21.0% ± 5.2%, and in their ACAT2−/− counterparts it fell from 35.1% ± 4.5% to 7.9% ± 0.8%.

Subscribe to