Tsutomu Masaki, Masato Okada, Masaki Tokuda, Yasushi Shiratori, Osamu Hatase, Mutsunori Shirai, Mikio Nishioka, Masao Omata – 30 December 2003 – The proto‐oncogene product pp60c‐src is the cellular homologue of the Rous sarcoma transforming gene, and it is a non–receptor‐linked and membrane‐associated tyrosine kinase. There is a close correlation between elevated pp60c‐src activity and cell transformation. We have recently reported that pp60c‐src was activated in hepatocellular carcinoma (HCC) of human and Long‐Evans cinnamon (LEC) rats.

Andrew L. Mason, Johnson Y. Lau, Nicole Hoang, KePing Qian, Graeme J. Alexander, Lizhe Xu, Linsheng Guo, Sheraj Jacob, Fredric G. Regenstein, Robert Zimmerman, James E. Everhart, Clive Wasserfall, Noel K. Maclaren, Robert P. Perrillo – 30 December 2003 – While patients with liver disease are known to have a higher prevalence of glucose intolerance, preliminary studies suggest that hepatitis C virus (HCV) infection may be an additional risk factor for the development of diabetes mellitus.

Itsuki Ajioka, Toshihiro Akaike, Yoshifumi Watanabe – 30 December 2003 – A complex vascular network forms an important component of the liver architecture. This network is essential for the supply of oxygen and nutrients to cells and delivery of molecules for metabolic exchange. In this study, we attempted to construct a vascular network in transplanted hepatic tissues and examined the effect of such network on tissue formation.

Cynthia R. Gross, Michael Malinchoc, W. Ray Kim, Roger W. Evans, Russell H. Wiesner, Janice L. Petz, Jeffrey S. Crippin, Goran B. Klintmalm, Marlon F. Levy, Paola Ricci, Terry M. Therneau, E. Rolland Dickson – 30 December 2003 – Liver transplantation (LT) is an established therapy for patients with end‐stage primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). In this report, we describe the health status and quality of life (QOL) in patients with these cholestatic liver diseases before and after LT.

Frieder Berr, Marcus Wiedmann, Joachim Mössner, Andrea Tannapfel, Frank Schmidt – 30 December 2003

Josep M. Llovet, Javier Bustamante, Antoni Castells, Ramon Vilana, Maria Del Carmen Ayuso, Margarita Sala, Concepció Brú, Joan Rodés, Jordi Bruix – 30 December 2003 – This study analyzed the natural history and prognostic factors of patients with nonsurgical hepatocellular carcinoma (HCC). Twenty variables from 102 cirrhotic patients with HCC who were not treated within prospective randomized controlled trials (RCT) were investigated through uni‐ and multivariate analyses.

Anne‐Marie Bonnand, E. Jenny Heathcote, Keith D. Lindor, Renée Eugénie Poupon – 30 December 2003 – We determined whether the normalization of serum bilirubin level (SBL) induced by ursodeoxycholic acid (UDCA) therapy was associated with an improved clinical outcome in patients with primary biliary cirrhosis (PBC). We estimated the prognostic values of SBL measured after 6 months of UDCA treatment for survival free of orthotopic liver transplantation (OLT). We used a database of 548 patients with PBC followed in three trials of UDCA.

Christian Pichoud, Béatrice Seignères, Zhirui Wang, Christian Trépo, Fabien Zoulim – 30 December 2003 – Prolonged therapy for chronic hepatitis B (HBV) with nucleoside analogs may result in the emergence of HBV mutants resistant to antivirals. Here, we describe the transient selection of an HBV polymerase gene mutant that was associated with viral persistence in an immune competent patient treated with famciclovir. Viral polymerase gene sequence was analyzed directly on polymerase chain reaction (PCR) products and also after cloning.

F Nadori, B Lardeux, M Rahmani, A Bringuier, A Durand‐Schneider, D Bernuau – 30 December 2003 – Activation of the transcriptional regulator AP‐1, a dimeric complex formed of various combinations of Fos and Jun proteins, is a key step in the cellular response to mitogens. Because different dimers are believed to display different regulatory functions, we hypothesized that transformed cells that lack normal growth constraints might display AP‐1 dimers that are different from those of normal cells.

V Neaud, S Faouzi, J Guirouilh, B Le Bail, C Balabaud, P Bioulac‐Sage, J Rosenbaum – 30 December 2003 – The stroma of hepatocellular carcinomas (HCC) is infiltrated with myofibroblasts (MFs). Preliminary in vivo data have suggested that liver MF express hepatocyte growth factor (HGF), a cytokine that has been implicated in several tumor models. Our aim was to investigate the role of MF and HGF in HCC. Cultured liver MF expressed HGF messenger RNA (mRNA) and secreted HGF in their medium, as shown by Western blot, immunoprecipitation, and enzyme‐linked immunosorbent assay (ELISA).