Engraftment assessment in human and mouse liver tissue after sex‐mismatched liver cell transplantation by real‐time quantitative PCR for Y chromosome sequences

Ling‐Jia Wang, Yong Ming Chen, David George, Francois Smets, Etienne M. Sokal, Eric G. Bremer, Humberto E. Soriano – 30 December 2003 – Transplanted hepatocytes can engraft, proliferate, and function permanently in host animals. After one cell infusion, however, engrafted hepatocytes constitute only between 1 in 200 to 1 in 3000 host liver cells. Although transplanted cells can be identified using biochemical and molecular techniques, more accurate methods are needed to evaluate interventions that could improve cell engraftment rates.

Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria

Francis Y. Yao, Linda Ferrell, Nathan M. Bass, Peter Bacchetti, Nancy L. Ascher, John P. Roberts – 30 December 2003 – We previously proposed modified staging criteria for predicting acceptable outcome after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). These were solitary tumor ≤6.5 cm, or three or fewer nodules with the largest lesion ≤4.5 cm and total tumor diameter ≤8 cm, without gross vascular invasion (University of California, San Francisco [UCSF] criteria).

Donor evaluation, donor risks, donor outcome, and donor quality of life in adult‐to‐adult living donor liver transplantation

Andreas Pascher, Igor M. Sauer, Marc Walter, Enrique Lopez‐Haeninnen, Tom Theruvath, Antonino Spinelli, Ruth Neuhaus, Utz Settmacher, Andrea R. Mueller, Thomas Steinmueller, Peter Neuhaus – 30 December 2003 – Right lobe living donor liver transplantation (LD‐LTx) is currently performed at an increasing number of transplant centers. Donor selection, donor safety, donor recovery, and postdonation psychological impairment are essential criteria to determine whether and under which conditions LD‐LTx is justifiable.

Liver transplantation for hepatocellular carcinoma: Analysis of survival according to the intention‐to‐treat principle and dropout from the waiting list

Francis Y. Yao, Nathan M. Bass, Bev Nikolai, Timothy J. Davern, Robert Kerlan, Victor Wu, Nancy L. Ascher, John P. Roberts – 30 December 2003 – A major obstacle for orthotopic liver transplantation (OLT) as treatment for hepatocellular carcinoma (HCC) is tumor growth resulting in dropout from the waiting list for OLT. There is a paucity of data on survival according to intention‐to‐treat analysis and the rate of dropout from the waiting list for OLT among patients with HCC.

Donor and recipient outcomes in right lobe adult living donor liver transplantation

Rafik M. Ghobrial, Sammy Saab, Charles Lassman, David S.K. Lu, Steven Raman, Piyagorn Limanond, Greg Kunder, Karyn Marks, Farin Amersi, Dean Anselmo, Pauline Chen, Douglas Farmer, Steven Han, Francisco Durazo, Leonard I. Goldstein, Ronald W. Busuttil – 30 December 2003 – Severe donor organ shortage has provided the impetus for adult living donor liver transplantation (ALDLT). Despite rapid implementation and expansion of the procedure, outcome analysis of ALDLT is still incomplete. This study analyzed both donor and recipient outcomes after ALDLT at a single center.

Socioeconomic status does not affect the outcome of liver transplantation

Hwan Y. Yoo, Violetta Galabova, David Edwin, Paul J. Thuluvath – 30 December 2003 – The outcome of liver transplantation is dependent on many factors. It was suggested that racial disparities in outcome may be related to differences in socioeconomic status (SES). In this retrospective study, we analyzed the effect of SES on graft and patient survival. Two hundred seventy‐six adult patients who underwent liver transplantation at our institution from July 1988 to June 2001 were included in the analysis.

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