Oscar Escribano, María Dolores Fernández‐Moreno, José Antonio Zueco, Cesar Menor, Jesus Fueyo, Rosa María Ropero, Inés Diaz‐Laviada, Irene D. Román, Luis G. Guijarro – 30 December 2003 – This study was designed to characterize insulin receptor substrate‐4 (IRS‐4) in isolated rat hepatocytes and to examine its role in liver regeneration. Subcellular fractionation revealed that 85% of IRS‐4 is located at isolated hepatocyte plasma membranes. The distribution of IRS‐4 among intracellular compartments remained unchanged in insulin‐stimulated cells.

Steven W. M. Olde Damink, Nicolaas E. P. Deutz, Peter B. Soeters, Rajiv Jalan – 30 December 2003

Nasir Khokhar, Naila Asif, Omar S. Khokhar – 30 December 2003

Paul D. Berk – 30 December 2003

Carlo Giannini, Serban Morosan, J. Guilherme Tralhao, Jacques Emmanuel Guidotti, Serena Battaglia, Karine Mollier, Laurent Hannoun, Dina Kremsdorf, Helene Gilgenkrantz, Pierre Charneau – 30 December 2003 – Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplantation.

Chang Han, A. Jake Demetris, George K. Michalopoulos, Qimin Zhan, James H. Shelhamer, Tong Wu – 30 December 2003 – Ligands of peroxisome proliferator‐activated receptor‐γ (PPARγ) induce differentiation and growth inhibition in several human cancers. However, the role of PPARγ ligands in the growth control of human cholangiocarcinoma cells remains unknown. This study was designed to investigate the biological functions and molecular mechanisms of PPARγ ligands in the growth regulation of human cholangiocarcinoma cells.

Agostino Colli, Sara Massironi, Marco Anreoletti – 30 December 2003

Michael Bauer – 30 December 2003

Kyung‐Ran You, Ming‐Jie Liu, Xue‐Ji Han, Zee‐Won Lee, Dae‐Ghon Kim – 30 December 2003 – The transcription factor CHOP/GADD153 is reportedly induced by cellular stresses such as UV light, genotoxic agents, and protein misfolding in the endoplasmic reticulum. However, the mechanism whereby induction of the GADD153 gene is linked to a downstream pathway is still unclear.

Anil Darbari, Keith M. Sabin, Craig N. Shapiro, Kathleen B. Schwarz – 30 December 2003 – The epidemiology of primary hepatic malignancies in U.S. children is poorly characterized. We analyzed the incidence, mortality, and characteristics of primary hepatic malignancies in U.S. residents less than 20 years of age. Fatal primary hepatic malignancies in persons less than 20 years of age, between 1979 and 1996, were identified using the multiple‐cause‐of‐death database (National Center for Health Statistics).