Mechanism of action of ribavirin in the combination treatment of chronic HCV infection
Johnson Y. N. Lau, Robert C. Tam, T. Jake Liang, Zhi Hong – 30 December 2003
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Anna S. F. Lok, Brian J. McMahon, Henry Bodenheimer – 30 December 2003
The SJL/J mouse is not a model for PBC
Motoko Sasaki, S. Alice Long, Judy Van de Water, Xiao‐Song He, Len Shultz, Ross L. Coppel, Aftab Ansari, Yasuni Nakanuma, M. Eric Gershwin – 30 December 2003
High prevalence of HCV infection in patients with B‐cell non‐Hodgkin's lymphoma: Comparison with birth cohort– and sex‐matched blood donors in a Japanese population
Yasuharu Imai, Masahiko Ohsawa, Hideo Tanaka, Shinji Tamura, Hiroyuki Sugawara, Jun Kuyama, Kazuto Fukada, Takeshi Yonezawa M.D., Yuji Matszawa – 30 December 2003
Tissue typing for HFE mutations
Stuart Raaka, Kier V. Huehnergarth, Kris V. Kowdley, Mary P. Bronner – 30 December 2003
The in vivo apoptotic effect of interferon alfa‐2b on rat preneoplastic liver involves Bax protein
María de Luján Alvarez, Juan Pablo Cerliani, Juan Monti, Cristina Carnovale, María Teresa Ronco, Gerardo Pisani, María Cristina Lugano, María Cristina Carrillo – 30 December 2003 – To determine whether interferon alfa (IFN‐α) prevents in vivo oncogenesis in very‐early‐stage cancer cells, we evaluated the action of IFN‐α2b over preneoplastic foci in rats.
The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures
Christina Ziemann, Dirk Schäfer, Gudrun Rüdell, Georg F. Kahl, Karen I. Hirsch‐Ernst – 30 December 2003 – Overexpression of mdr1‐type P‐glycoproteins (P‐gps) is thought to contribute to primary chemotherapy resistance of untreated hepatocellular carcinoma. However, mechanisms of endogenous multidrug resistance 1 (mdr1) gene activation still remain unclear.
Intestinal mucosal alterations in experimental cirrhosis in the rat: Role of oxygen free radicals
Anup Ramachandran, Ramamoorthy Prabhu, Simmy Thomas, Jayasree Basivi Reddy, Anna Pulimood, Kunissery A. Balasubramanian – 30 December 2003 – Cirrhosis is associated with altered gastrointestinal function, and bacterial translocation from the gut plays an important role in the etiology of spontaneous bacterial peritonitis (SBP) seen in this condition. Although alterations in gut motility and intestinal permeability are recognized in cirrhosis, the intestinal damage at the cellular and subcellular levels is not well understood.
Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: A meta‐analysis
Rafael Bañares, Agustín Albillos, Diego Rincón, Sonia Alonso, Mónica González, Luis Ruiz‐del‐Arbol, Magdalena Salcedo, Luis‐Miguel Molinero – 30 December 2003 – Endoscopic therapy, involving either injection sclerosis or band ligation, is considered the intervention of first choice for acute variceal bleeding (AVB). Pharmacologic agents have also been shown to be highly effective in the control of the bleeding episode.
Variants of two major T cell epitopes within the hepatitis B surface antigen are not recognized by specific T helper cells of vaccinated individuals
Tanja Bauer, Klaus Weinberger, Wolfgang Jilg – 30 December 2003 – Several naturally occurring variants of immunogenic T cell epitopes were identified within the hepatitis B surface antigen (HBsAg). The effect of these variants on the cellular immune response was studied in individuals vaccinated against HBV. Class‐II restricted T‐cell responses of 30 vaccinees were analyzed after stimulation of peripheral blood mononuclear cells (PBMCs) with 4 synthetic peptides representing the 4 T‐cell epitopes of HBsAg known as of yet.