Robert L. Carithers – 30 December 2003 – Liver transplantation has revolutionized the care of patients with end‐stage liver disease. Liver transplantation is indicated for acute or chronic liver failure from any cause. Because there are no randomized controlled trials of liver transplantation versus no therapy, the efficacy of this surgery is best assessed by carefully comparing postoperative survival with the known natural history of the disease in question.
Menahem Ben‐Haim, Sasan Roayaie, Ming Q. Ye, Swan N. Thung, Sukru Emre, Thomas A. Fishbein, Patricia M. Sheiner, Charles M. Miller, Myron E. Schwartz – 30 December 2003 – Hepatic epithelioid hemangioendothelioma (HEHE) is a rare tumor with an unpredictable course and prognosis. The aim of this study is to describe our experience with liver resection, as well as transplantation, in the treatment of this tumor. We retrospectively analyzed the clinical features, pathological findings, and postoperative results in a series of 11 patients presenting between 1990 and 1998.
Santiago Mera, Julio Santoyo, Miguel Angel Suárez, José Antonio Bondía, Antonio Jes Cabello, Manuel Jiménez, Marta Ribeiro, José Luis Fernández‐Aguilar, José Antonio Pérez‐Daga, Agustín de la Fuente – 30 December 2003 – Transplantation of a small liver into a large patient may cause problems with correct reperfusion of the graft because of torsion of the hepatic pedicle, leading to malfunction of the transplanted organ. We describe the case of a 60‐year‐old man with alcoholic cirrhosis and hepatitis B virus who received a small‐sized liver graft.
Geoffrey W. McCaughan, Jenean Spencer, David Koorey, Scott Bowden, Angeline Bartholomeusz, Margaret Littlejohn, Deborah Verran, Albert K.K. Chui, A.G. Ross Sheil, Robert M. Jones, Stephen A. Locarnini, Peter W. Angus – 30 December 2003 – Recurrent hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality after liver transplantation. Recently, antiviral therapy, such as lamivudine, has become available for prophylaxis against HBV reactivation posttransplantation and for the treatment of HBV recurrent disease.
E. Jenny Heathcote, Julie Stone, Karen Cauch‐Dudek, Raoul Poupon, Olivier Chazouilleres, Keith D. Lindor, Jan Petz, E. Rolland Dickson, Reneé E. Poupon – 30 December 2003 – As ursodeoxycholic acid (UDCA) delays the need for transplantation, this could result in patients with more comorbid disease, therefore more likely to have a worse outcome posttransplantation. The aim of this study is to compare posttransplantation outcome in patients who received UDCA versus placebo who subsequently required a liver transplant.
Cynthia A. Bradham, Peter Schemmer, Robert F. Stachlewitz, Ronald G. Thurman, David A. Brenner – 30 December 2003 – Reperfusion after liver transplantation results in the induction of tumor necrosis factor‐α (TNFα) as well as activation of the stress‐associated signaling proteins, c‐JunN‐terminal kinase (JNK), activating protein‐1 (AP‐1), and nuclear factor‐κB (NF‐κB).
Abd El El‐Desoky, Alexander Seifalian, Mark Cope, David Delpy, Brian Davidson – 30 December 2003 – Near‐infrared spectroscopy (NIRS) is a novel method for the measurement of tissue oxygenation and may have a role in monitoring liver oxygenation and viability. The aim of this study is to validate the application of NIRS for monitoring hepatic tissue oxygenation. Large Landrace pigs (n = 12) underwent laparotomy and liver exposure. Total hepatic blood flow (THBF) was measured by the Transonic Medical Flowmeter system.
Laura W. Lamps, Kelly Carson, Anne L. Bradley, C. Wright Pinson, Joyce E. Johnson, Alice C. Coogan, Ellen B. Hunter, Pierre A. Clavien, Mary Kay Washington – 30 December 2003 – Cirrhosis and portal hypertension may be associated with pulmonary hypertension and pulmonary dysfunction. However, morphological pulmonary vascular lesions in patients with cirrhosis have not been well characterized morphometrically.
Alison L. Doughty, Dorothy M. Painter, Geoffrey W. McCaughan – 30 December 2003 – Detection of hepatitis C virus (HCV) antigens in liver tissue provides important diagnostic and pathological information. Limited studies have been performed on tissue taken after liver transplantation for HCV. In this study, serial post–liver transplantation biopsy tissue from patients with recurrent HCV was tested, with particular interest in patients showing severe cholestatic hepatitis. HCV‐related antigens were detected using the commercial monoclonal antibody, Tordji‐22.