David G. Rickheim, Christopher J. Nelsen, John T. Fassett, Nikolai A. Timchenko, Linda K. Hansen, Jeffrey H. Albrecht – 30 December 2003 – Substantial evidence suggests that cyclin D1 plays a pivotal role in the control of the hepatocyte cell cycle in response to mitogenic stimuli, whereas the closely related protein cyclin D3 has not been extensively evaluated. In the current study, we examined the regulation of cyclins D1 and D3 during hepatocyte proliferation in vivo after 70% partial hepatectomy (PH) and in culture.

Lorenza Tacchini, Daniela Fusar Poli, Aldo Bernelli‐Zazzera, Gaetano Cairo – 30 December 2003 – Iron‐catalyzed production of reactive oxygen species is a cause of liver injury after ischemia/reperfusion (I/R). The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R. The molecular mechanisms controlling TfR gene expression in vivo during I/R of rat liver were investigated by molecular biology procedures. We also analyzed transferrin‐bound iron uptake into surviving liver slices.

Stephan R. Vavricka, Jessica Van Montfoort, Huy Riem Ha, Peter J. Meier, Karin Fattinger – 30 December 2003 – The antibiotics rifamycin SV and rifampicin substantially reduce sulfobromophthalein (BSP) elimination in humans. In rats, rifamycin SV and rifampicin were shown to interfere with hepatic organic anion uptake by inhibition of the organic anion transporting polypeptides Oatp1 and Oatp2. Therefore, we investigated the effects of rifamycin SV and rifampicin on the OATPs of human liver and determined whether rifampicin is a substrate of 1 or several of these carriers.

Christophe Duvoux, David Zanditenas, Christophe Hézode, Anthony Chauvat, Jean‐Luc Monin, Françoise Roudot‐Thoraval, Ariane Mallat, Daniel Dhumeaux – 30 December 2003 – Treatment of hepatorenal syndromes (HRSs) is currently based on vasopressin analogs. The aim of this pilot study was to evaluate the efficacy and safety of noradrenalin (NA) in the treatment of type 1 HRS.

Ira J. Fox – 30 December 2003

Vinicio Carloni, Raffaella M. S. DeFranco, Alessandra Caligiuri, Alessandra Gentilini, Silvia Cappadona Sciammetta, Elisabetta Baldi, Benedetta Lottini, Paolo Gentilini, Massimo Pinzani – 30 December 2003 – The biologic effects of growth factors are dependent on cell adhesion, and a cross talk occurs between growth factors and adhesion complexes. The aim of the present study was to evaluate the influence of cell adhesion on the major intracellular signaling pathways elicited by platelet‐derived growth factor (PDGF) in hepatic stellate cells (HSC).

Florian van Bömmel, Thomas Wünsche, Dirk Schürmann, Thomas Berg – 30 December 2003

Agustín Albillos, Rafael Bañares – 30 December 2003

Ayman A. Abdo, Samuel S. Lee – 30 December 2003

Yong‐Han Paik, Robert F. Schwabe, Ramón Bataller, Maria P. Russo, Christian Jobin, David A. Brenner – 30 December 2003 – Bacterial lipopolysaccharide (LPS) stimulates Kupffer cells and participates in the pathogenesis of alcohol‐induced liver injury. However, it is unknown whether LPS directly affects hepatic stellate cells (HSCs), the main fibrogenic cell type in the injured liver. This study characterizes LPS‐induced signal transduction and proinflammatory gene expression in activated human HSCs.