Kinetics of hepatitis B surface antigen–specific immune responses in acute and chronic hepatitis B or After HBs vaccination: Stimulation of the in vitro antibody response by interferon gamma

Wulf Otto Böcher, Sabine Herzog‐Hauff, Jörg Schlaak, Karl‐Hermann Meyer zum Büschenfelde, Hanns Friedrich Löhr – 30 December 2003 – Because cellular and humoral immune responses against the hepatitis B virus (HBV) surface antigen (HBs) might be crucial to overcome HBV infection, HBs‐specific B‐ and T‐cell responses of HBV patients and HBs vaccine recipients were analyzed quantitatively and functionally.

Reduction of health‐related quality of life in chronic hepatitis C and improvement with interferon therapy

Herbert L. Bonkovsky, J. Michael Woolley – 30 December 2003 – The natural history, prognosis, and clinical significance of chronic hepatitis C are highly variable and somewhat controversial. The purpose of this study was to evaluate the effect of chronic hepatitis C infection on patients' perceptions of health‐related quality of life (HRQOL) and to evaluate whether treatment with interferon improves HRQOL.

Restoration of serum albumin levels in nagase analbuminemic rats by hepatocyte transplantation

Ran Oren, Mariana D. Dabeva, Petko M. Petkov, Ethel Hurston, Ezio Laconi, David A. Shafritz – 30 December 2003 – Recently, we described a new strategy for hepatocyte transplantation, using retrorsine/partial hepatectomy (PH) in a DPPIV− mutant Fischer rat model. Treatment of rats with retrorsine, a pyrrolizidine alkaloid, blocks endogenous hepatocytes from proliferating, so that after exposure to this agent coupled with PH and hepatocyte transplantation, transplanted hepatocytes selectively repopulate the liver.

Brain histamine levels and neocortical slow‐wave activity in rats with portacaval anastomosis

Violina Lozeva, Antti Valjakka, Eeva Anttila, Ewen MacDonald, Mikko Hippeläinen, Leena Tuomisto – 30 December 2003 – To determine whether the increased histamine levels in the brain of rats with portacaval anastomosis (PCA) are associated with the development of sleep disturbances during the light phase, the neocortical slow‐wave activity of PCA‐operated rats was examined with electroencephalography (EEG) 1 month and 6 months after the surgery.

Nitric oxide reduces nontransferrin‐bound iron transport in HepG2 cells

Donatella Barisani, Gaetano Cairo, Enrico Ginelli, Anna Marozzi, Dario Conte – 30 December 2003 – Nitric oxide (NO) donors S‐nitroso‐N‐acetylpenicillamine (SNAP) and sodium nitroprusside (SNP) modulate iron regulatory protein (IRP) activity and may, therefore, affect iron uptake through transferrin receptor expression. However, iron also enters the cell as nontransferrin‐bound iron (NTBI), and the aim of this study was to evaluate the effects of NO donors on NTBI transport in HepG2 cells, a model of liver physiology.

Glutathione peroxidase–deficient mice are more susceptible to neutrophil‐mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress

Hartmut Jaeschke, Ye‐Shih Ho, Michael A. Fisher, Judy A. Lawson, Anwar Farhood – 30 December 2003 – Neutrophils contribute to hepatocellular injury in a number of acuteinflammatory reactions. However, the molecular mechanism of parenchymal cell injury remains controversial. To address the issue of whether or not reactive oxygen species (ROS) are important in the injury process, we used the galactosamine/endotoxin (Gal/ET) model of acute liver failure, which involves a neutrophil‐mediated parenchymal cell injury.

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