Abnormal intracellular distribution of O6‐alkylguanine‐DNA‐alkyltransferase in hepatitis B cirrhotic human liver: A potential cofactor in the development of hepatocellular carcinoma

S M Lee, B C Portmann, G P Margison – 1 November 1996 – The expression of O6‐alkylguanine‐DNA‐alkyltransferase (ATase), which is responsible for repair of the promutagenic and cytotoxic DNA lesion O6‐alkylguanine, was examined by immunostaining in a series of liver sections from normal and hepatitis‐B cirrhosis patients using a polyclonal anti‐human ATase antiserum. In 10 normal liver sections, the ATase staining was predominantly nuclear and very intense in the majority of the hepatocytes with a panacinar distribution.

No association between genetic hemochromatosis and α1‐antitrypsin deficienc

S Fargion, F Bissoli, A L Fracanzani, E Suigo, C Sergi, E Taioli, R Ceriani, V Dimasi, A Piperno, M Sampietro, G Fiorelli – 1 November 1996 – Genetic hemochromatosis and α1‐antitrypsin (AAT) deficiency are frequent in white populations. Conflicting data on the association of the two conditions and on the severity of the disease in those in whom these disorders coexist have emerged from analyses of small numbers of patients.

Evaluation of a new endoscopic index to predict first bleeding from the upper gastrointestinal tract in patients with cirrhosis

M Zoli, C Merkel, D Magalotti, G Marchesini, A Gatta, E Pisi – 1 November 1996 – The aim of this study was to prospectively evaluate the usefulness of the Italian Liver Cirrhosis Project (ILCP) classification of esophageal varices, together with the gastric features of portal hypertension, in predicting the first upper gastrointestinal bleeding in cirrhosis. The efficiency of these endoscopic parameters in predicting bleeding was also compared with the efficiency of the North Italian Endoscopic Club (NIEC) index.

Intracaval endovascular ultrasonography for preoperative assessment of retrohepatic inferior vena cava infiltration by malignant hepatic tumors

T Kaneko, A Nakao, S Nomoto, T Endo, S Itoh, H Takagi – 1 November 1996 – The accurate diagnosis of inferior vena cava infiltration is important not only for preoperative staging but also for performing surgery for hepatic tumor involving the inferior vena cava (IVC). We investigated the diagnostic value of intracaval endovascular ultrasonography (ICEUS) in the diagnosis of invasion of the IVC by a prospective study of 30 consecutive patients with hepatic tumors with possible invasion of the IVC.

Fibrolamellar carcinoma of the liver: Composition of the extracellular matrix and expression of cell‐matrix and cell‐cell adhesion molecules

J Scoazec, J Flejou, A D'Errico, M Fiorentino, A Zamparelli, A Bringuier, G Feldmann, W F Grigioni – 1 November 1996 – We have analyzed the composition of the tumor stroma and the expression of cell‐matrix and cell‐cell adhesion molecules in 11 cases of fibrolamellar carcinoma of the liver (FLC), in comparison with 34 cases of hepatocellular carcinoma and 8 cases of focal nodular hyperplasia.

Kupffer cell production of cytokine‐induced neutrophil chemoattractant following ischemia/reperfusion injury in rats

N Hisama, Y Yamaguchi, T Ishiko, N Miyanari, O Ichiguchi, M Goto, K Mori, K Watanabe, K Kawamura, S Tsurufuji, M Ogawa – 1 November 1996 – We investigated the role of hepatic macrophages in the inflammatory response following reperfusion injury by blocking Kupffer cell phagocytosis with gadolinium chloride (GdCl3). Liver ischemia was induced in rats by occluding the portal vein for 30 minutes. A bolus of GdCl3 (7 mg/kg) was injected intravenously 1 and 2 days before surgery.

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