Geoffrey McCaughan, Peter Angus, Scott Bowden, Tim Shaw, Allan Breschkin, Ross Sheil, Stephen Locarnini – 1 November 1996 – Retransplantation for hepatitis B—related liver allograft failure is rarely successful. Recurrence of infection is almost universal, and the second allograft is invariably lost more rapidly than the first. In a recent multicenter study, only 1 of 20 hepatitis B virus (HBV)—positive patients who underwent liver retransplantation survived beyond 6 months.

S Kaur, L Rybicki, B R Bacon, J L Gollan, V K Rustgi, W D Carey – 1 November 1996 – Chronic viral hepatitis frequently goes undetected until cirrhosis develops. Although the effect of interferon on the natural history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in asymptomatic persons is unknown, treatment may modify the course of the infection, producing cures in some. In September 1992, screening for HBV and HCV was offered in 40 centers throughout the United States. Demographic features, potential risk factors, and symptoms were studied.

M Sasaki, Y Nakanuma, Y S Kim – 1 November 1996 – To date, seven apomucins have been characterized and their expression in malignant and premalignant lesions is under evaluation. In this study, we examined the expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins in cholangiocarcinoma (CC) and biliary epithelial dysplasia.

J Van de Water, L B Gerson, L D Ferrell, J R Lake, R L Coppel, K P Batts, R H Wiesner, M E Gershwin – 1 November 1996 – Whether primary biliary cirrhosis (PBC) recurs after liver transplantation has remained an interesting and controversial issue; rejection, viral hepatitis, and drug effects all may mimic recurrent PBC histologically and biochemically. Furthermore, reliable clinical criteria for PBC recurrence are lacking.

J F Debatin, B Zahner, C Meyenberger, B Romanowski, W Schopke, B Marincek, W A Fuchs – 1 November 1996 – Flow volume in the azygos venous system was quantitated with Cine‐phase contrast (PC) velocity mapping in volunteers and compared with patients with known portal hypertension, who were referred for transjugular intrahepatic portosystemic shunt (TIPS) placement. Subsequently, the TIPS‐induced hemodynamic effects on portal and azygos flow were analyzed.

A Ordinas, G Escolar, I Cirera, M Vinas, F Cobo, J Bosch, J Teres, J Rodés – 1 November 1996 – A defect in hemostasis has been repeatedly reported in patients with cirrhosis. However, the nature of this defect has not been fully characterized. We explored adhesive and cohesive functions of platelets from cirrhotic patients at different stages of disease development. The response of platelets to standard activating agents was tested by aggregometric procedures.

P Jouet, A Meyrier, F Mal, P Callard, C Guettier, D Stordeur, J Trinchet, M Beaugrand – 1 November 1996 – When renal lesions are suspected in patients with cirrhosis, clotting disorders often preclude percutaneous renal biopsy. This study was undertaken to determine whether transjugular renal biopsy is possible, safe, and useful in such patients. From 1987 to 1994, 70 patients with cirrhosis and clotting disorders underwent transjugular renal biopsies, providing renal tissue in 55.

T Adachi, S Nakashima, S Saji, T Nakamura, Y Nozawa – 1 November 1996 – Hepatocyte growth factor (HGF) activated phospholipase D (PLD) in primary‐cultured rat hepatocytes, as assessed by the formation of phosphatidylbutanol (PBut), a specific and stable product of PLD activity in the presence of 0.3% butanol. PLD hydrolyzes phosphatidylcholine to choline and phosphatidic acid (PA), which is further metabolized to diacylglycerol (DG) by PA phosphohydrolase (PAP). In HGF‐stimulated hepatocytes, butanol prevented the formation of PA and DG.

Rahul M. Jindal, N. Harris, Huey M. McDaniel, Glen Lehman, Stuart Sherman – 1 November 1996 – Choledochal cysts have generally been described to communicate with the biliary system. We recently saw three adult patients in whom we could not demonstrate biliary communication between the cyst and the biliary tree, despite a carefully performed endoscopic cholangiopancreatography (ERCP). These cases may represent a variant of type II choledochal cysts.

T Shaw, S S Mok, S A Locarnini – 1 November 1996 – The deoxyguanosine analog penciclovir (PCV; 9‐[4‐hydroxy‐3‐hydroxymethyl‐but‐1‐yl]guanine), has shown potent antiviral activity against herpes viruses and hepadnaviruses. Efficacy against chronic hepatitis B virus (HBV) infection has been demonstrated in an animal model and in recent clinical trials of famciclovir, the oral form of PCV.