Venous hemodynamics in living donor right lobe liver transplantation

Gabriel E. Gondolesi, Sander Florman, Cal Matsumoto, Ruoqing Huang, Thomas M. Fishbein, Patricia A. Sheiner, Myron E. Schwartz, Sukru Emre, Swan Thung, Robert Shapiro, Charles M. Miller – 30 December 2003 – We evaluated the influence of portal and hepatic venous hemodynamics on the immediate and 3‐month postoperative function of living donor right lobe grafts. Portal velocity was measured prospectively by ultrasound in 14 consecutive donor/recipient pairs. Velocity was converted to flow with the Moriyasu formula.

Living donor liver transplantation for giant hepatic hemangioma with Kasabach‐Merritt syndrome with a posterior segment graft

Yuji Kumashiro, Mureo Kasahara, Kazuhiro Nomoto, Masaru Kawai, Katsuya Sasaki, Tetsuya Kiuchi, Koichi Tanaka – 30 December 2003 – We present a case of a giant hepatic hemangioma with Kasabach‐Merritt syndrome, which was cured by living donor liver transplantation. A 48‐year‐old woman complained of abdominal fullness and appetite loss. The laboratory data showed disseminated intravascular coagulation and a morphologic evaluation revealed a giant hepatic hemangioma involving both lobes of the liver.

Safe use of livers from donors with positive hepatitis B core antibody

Cosme Manzarbeitia, David J. Reich, Jorge A. Ortiz, Kenneth D. Rothstein, Victor R. Araya, Santiago J. Munoz – 30 December 2003 – Thirty‐five patients received liver transplants using liver donors who had positive test results for the hepatitis B core antibody (HBcAb). In the same time frame, 195 patients received HBcAb‐negative liver donors. Mean follow up for patients receiving HBcAb‐positive donors was 25 months. All patients receiving HBcAb‐positive donors were monitored for recurrence of hepatitis B (HBV) with HBV DNA assays.

Evidence of differential risk for posttransplantation malignancy based on pretransplantation cause in patients undergoing liver transplantation

Sanjiv Saigal, Suzanne Norris, Paolo Muiesan, Mohamed Rela, Nigel Heaton, John O'Grady – 30 December 2003 – Organ transplant recipients are considered to be at greater risk for developing malignancy because of the prolonged immunosuppression associated with organ grafting. The purpose of this study is to determine risk factors, clinical characteristics, and outcomes of de novo nonlymphoid malignancies after liver transplantation from a large single‐center series.

Predicting the probability of progression‐free survival in patients with small hepatocellular carcinoma

Steve J. Cheng, Richard B. Freeman, John B. Wong – 30 December 2003 – Allocation of cadaveric livers to patients based on such objective medical urgency data as the Model for End‐Stage Liver Disease (MELD) score may not benefit patients with small hepatocellular carcinomas (HCCs). To ensure that these patients have a fair opportunity of receiving a cadaveric organ, the risk for death caused by HCC and tumor progression beyond 5 cm should be considered.

Post–liver transplantation diabetes mellitus: An association with hepatitis C

Ahmad A. AlDosary, Alnoor S. Ramji, Thomas G. Elliott, Sandra M. Sirrs, David M. Thompson, Siegfried R. Erb, Urs P. Steinbrecher, Eric M. Yoshida – 30 December 2003 – A retrospective study was performed on all liver transplant recipients from British Columbia from 1989 to March 2000 to determine the prevalence and predictive factors of diabetes mellitus (DM) post‐liver transplantation. DM was defined as hyperglycemia requiring treatment with insulin or oral hypoglycemic agents.

Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus–related liver injury

Amany Zekry, G. Alex Bishop, David G. Bowen, Margaret M. Gleeson, Seven Guney, Dorothy M. Painter, Geoffrey W. McCaughan – 30 December 2003 – Recurrent chronic hepatitis, cholestatic hepatitis, and acute rejection in conjunction with hepatitis C virus (HCV) recurrence are well‐recognized clinical sequelae of reinfection of the hepatic allograft with HCV. The aim of this study is to characterize intrahepatic cytokine responses associated with reinfection of the allograft with HCV in these settings.

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