A tamoxifen‐inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver

Mounia Tannour‐Louet, Arlette Porteu, Sophie Vaulont, Axel Kahn, Mireille Vasseur‐Cognet – 30 December 2003 – The spatiotemporal control of somatic mutagenesis in mice is considered a promising step to determine the function of a given gene product in a defined population of cells at any given time during animal life and also to generate better mouse models of human diseases.

Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

Chung‐Mau Lo, Henry Ngan, Wai‐Kuen Tso, Chi‐Leung Liu, Chi‐Ming Lam, Ronnie Tung‐Ping Poon, Sheung‐Tat Fan, John Wong – 30 December 2003 – This randomized, controlled trial assessed the efficacy of transarterial Lipiodol (Lipiodol Ultrafluide, Laboratoire Guerbet, Aulnay‐Sous‐Bois, France) chemoembolization in patients with unresectable hepatocellular carcinoma.

Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism

Juan B. Miñana, Luis Gómez‐Cambronero, Ana Lloret, Federico V. Pallardó, Juan Del Olmo, Amparo Escudero, José M. Rodrigo, Antonio Pellíin, Juan R. Viña, José Viña, Juan Sastre – 30 December 2003 – Apoptosis plays an important role in the progression of alcohol‐induced liver disease to cirrhosis. Oxidative stress is an early event in the development of apoptosis. The major aim of this study was to study the conditions in which oxidative stress occurs in chronic alcoholism and its relationship with apoptosis of hepatocytes.

The in vivo apoptotic effect of interferon alfa‐2b on rat preneoplastic liver involves Bax protein

María de Luján Alvarez, Juan Pablo Cerliani, Juan Monti, Cristina Carnovale, María Teresa Ronco, Gerardo Pisani, María Cristina Lugano, María Cristina Carrillo – 30 December 2003 – To determine whether interferon alfa (IFN‐α) prevents in vivo oncogenesis in very‐early‐stage cancer cells, we evaluated the action of IFN‐α2b over preneoplastic foci in rats.

The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures

Christina Ziemann, Dirk Schäfer, Gudrun Rüdell, Georg F. Kahl, Karen I. Hirsch‐Ernst – 30 December 2003 – Overexpression of mdr1‐type P‐glycoproteins (P‐gps) is thought to contribute to primary chemotherapy resistance of untreated hepatocellular carcinoma. However, mechanisms of endogenous multidrug resistance 1 (mdr1) gene activation still remain unclear.

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