A G Johansson, T Lövdal, K Magnusson, T Berg, T Skogh – 1 July 1996 – Immune complexes were formed between dinitrophenylated human serum albumin (DNP‐HSA) and polyclonal rabbit immunoglobulin G (IgG) anti‐DNP antibodies at antibody excess. The antigen was labelled with isotope (125I‐tyramine‐cellobiose) or fluorochrome, (6‐[fluorescein‐5‐(and‐6)‐carboxamido] hexanoic‐acid, succinimidyl ester). The radiolabelled antigen, native or antibody complexed, was given intravenously to rats. Radioactivity was measured in various organs at 1 hour following injection.

F Kuipers, J M van Ree, M H Hofker, H Wolters, G I Veld, R Havinga, R J Vonk, H M Princen, L M Havekes – 1 July 1996 – Adaptation of cholesterol and bile acid synthesis and of biliary cholesterol secretion represent key metabolic responses to maintain cholesterol homeostasis and have been suggested to be influenced by apolipoprotein E (apoE) phenotype in humans. We have investigated hepatic metabolism and secretion of cholesterol into bile in homozygous apoE‐deficient (apoE ‐/‐) mice fed normal lab chow.

C Leveille‐Webster – 1 July 1996

Nancy L. Ascher – 1 July 1996 – In a 6 month open label, randomized, multi‐center trial, we compared the efficacy and safety of mycophenolate mofetil (MMF) with high dose intravenous steroids (IVS) for the treatment of refractory, acute cellular rejection in recipients of first or second cadaveric or living‐donor renal allografts. A total of 150 patients were enrolled and randomized in a 1‐to‐1 ratio to receive oral MMF 1.5 g twice daily (n = 77) or i.v.

Michael B. Fallon, Gary A. Abrams – 1 July 1996

M. Susan Mandell – 1 July 1996

1 July 1996

Eric Koffi, Vincent Moutardier, Alain Sauvanet, Roger Noun, Jean François Fléjou, Jacques Belghiti – 1 July 1996 – Cutaneous metastases arising along the exit site of an abdominal drain in one patient and within the operative wound in two others after resection of a hepatocellular carcinoma (HCC) are reported. All patients underwent curative hepatic resection, and cutaneous metastases occurred 9, 12, and 22 months after surgery respectively. Cutaneous metastases were not associated with intrahepatic recurrence and were treated by local excision.

S C Lu, J Cai, J Kuhlenkamp, W Sun, H Takikawa, O Takenaka, T Horie, J Yi, N Kaplowitz – 1 July 1996 – Eisai hyperbilirubinemic rats (EHBR) are mutant Sprague‐Dawley rats that exhibit impaired biliary organic anion and reduced glutathione (GSH) secretion. In addition, liver GSH levels are twice that of age‐ matched controls. The mechanisms for the defect in biliary GSH secretion and the increase in cell GSH are not fully understood. We previously showed that canalicular membrane‐enriched vesicles isolated from EHBR livers exhibited normal GSH transport.

M Yamauchi, Y Maezawa, Y Mizuhara, M Ohata, J Hirakawa, H Nakajima, G Toda – 1 July 1996