Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton‐associated protein thiols and forms plasma membrane blebs in rat hepatocytes
M Lekehal, D Pessayre, J M Lereau, C Moulis, I Fourasté, D Fau – 1 July 1996 – Several herbal remedies have produced hepatitis in humans. The medicinal plant, germander, was recalled after its use as an adjuvant to slimming diets resulted in an epidemic of hepatitis in France. We studied the hepatotoxicity of germander in isolated rat hepatocytes.