Immunonephelometric quantification of group‐specific component protein in patients with acute liver failure

F H Wians, W Lin, L P Brown, F V Schiodt, W M Lee – 30 December 2003 – Serum levels of group‐specific component (Gc) protein are useful in evaluating the likelihood of survival in patients with acute liver failure (ALF) who may be candidates for liver transplant surgery. Most methods for quantifying Gc protein concentration are either isotopic, manual, technically demanding, and/or time consuming to perform, and thus are not well suited for routine clinical use in a hospital setting.

Fas‐ and tumor necrosis factor receptor 1–dependent but not perforin‐dependent pathways cause injury in livers infected with an adenovirus construct in mice

Zhang‐Xu Liu, Sugantha Govindarajan, Shigefumi Okamoto, Gunther Dennert – 30 December 2003 – Intravenous injection of type 5 adenovirus, deleted in the E1 and E3 regions, is shown to result in expression of viral antigens in the liver, initiating lymphocyte infiltration and liver injury. Following this infection, induction of Fas ligand (FasL), tumor necrosis factor α (TNF‐α), and perforin mRNA are all demonstrable in the liver, pointing to a role of respective pathways in liver injury.

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